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- Zinc dibutyldithiocarbamate
Zinc dibutyldithiocarbamate API Manufacturers & Suppliers
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Zinc dibutyldithiocarbamate | CAS No: 136-23-2 | GMP-certified suppliers
A medication that assists in diagnosing allergic contact dermatitis through standardized epicutaneous patch testing in individuals aged six years and older.
Therapeutic categories
Primary indications
- Zinc dibutyldithiocarbamate is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older
Product Snapshot
- Zinc dibutyldithiocarbamate is supplied as a cutaneous patch test kit formulation
- It is primarily used for allergenic epicutaneous testing to support the diagnosis of allergic contact dermatitis
- The product holds approved status in the US market with experimental classification
Clinical Overview
The pharmacodynamics and mechanism of action of zinc dibutyldithiocarbamate are not explicitly characterized in available data. However, its role as a dermatological sensitizer situates it within the context of cell-mediated immune responses, particularly in provoking localized hypersensitivity reactions that facilitate diagnostic evaluation. The allergenic response likely involves increased histamine release and an immunologic cascade characteristic of delayed-type hypersensitivity.
Zinc dibutyldithiocarbamate contains divalent zinc cations complexed with dithiocarbamate ligands, classifying it among sulfur compounds and metal coordination complexes. The compound's physicochemical properties relevant to absorption, distribution, metabolism, and excretion (ADME) are not well-documented due to its application primarily as a topical diagnostic agent rather than a systemic therapeutic.
Safety considerations focus on its inherent allergenic potential, underpinning the necessity for controlled and standardized use within patch testing protocols. Careful formulation and concentration management minimize adverse reactions beyond intended sensitization. The compound is classified in regulatory contexts as approved for diagnostic use, with attention to its safety profile in clinical dermatology.
Notable commercial usages pertain exclusively to dermatological testing products rather than therapeutic brands, reflecting its specialized niche.
For pharmaceutical sourcing and procurement, quality considerations emphasize batch consistency, purity, and compliance with regulations governing allergenic substances. Suppliers should provide adequate documentation on impurity profiles, endotoxin levels, and stability to ensure reliable performance in standardized patch test formulations.
Identification & chemistry
| Generic name | Zinc dibutyldithiocarbamate |
|---|---|
| Molecule type | Small molecule |
| CAS | 136-23-2 |
| UNII | HNM5J934VP |
| DrugBank ID | DB14194 |
Formulation & handling
- Zinc dibutyldithiocarbamate is a small molecule with low water solubility, requiring consideration of appropriate solvent systems for cutaneous formulations. Its formulation is intended for cutaneous application, not suitable for oral or injectable routes. Stability and handling should account for potential sensitivity to oxidation and moisture due to the dithiocarbamate moiety.
Regulatory status
| Lifecycle | The API is currently marketed in the US, with patent protection expired as of 2023, allowing for generic competition and indicating a mature market phase. |
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| Markets | US |
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Supply Chain
| Supply chain summary | The manufacturing and supply landscape for Zinc dibutyldithiocarbamate includes a limited number of originator companies producing branded products primarily for the US market, as exemplified by the T.R.U.E. Test Thin-Layer Rapid Use Patch Test. There is no significant indication of global presence beyond the US, and patent expiry information is not evident, suggesting that generic competition may be limited or not yet fully established. |
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Zinc dibutyldithiocarbamate is a type of Antidotes, Deterrents, and Toxicologic Agents
Antidotes, Deterrents, and Toxicologic Agents are an important category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that play a critical role in healthcare and toxicology. These substances are designed to counteract the effects of poisons, toxins, and overdoses, thereby saving lives and preventing severe health consequences.
Antidotes are substances that neutralize the toxic effects of certain drugs, chemicals, or poisons. They work by either directly binding to the toxic substance or by blocking its harmful actions on the body. Antidotes are administered in emergency situations to quickly reverse the effects of poisoning and restore normal physiological functions.
Deterrents, on the other hand, are pharmaceutical agents used to discourage or prevent harmful behaviors, such as substance abuse. They are designed to make the ingestion or misuse of certain substances unpleasant or less desirable. Deterrents can be formulated to cause unpleasant side effects, such as nausea or vomiting, when a particular substance is consumed in excessive amounts.
Toxicologic agents encompass a broad range of pharmaceutical APIs used in toxicology studies and research. These substances are employed to investigate the toxicity, metabolism, and mechanisms of action of various chemicals and compounds. Toxicologic agents are vital for understanding the potential hazards and risks associated with certain substances, ensuring the safety of drugs, and developing effective treatments for poisoning cases.
In conclusion, Antidotes, Deterrents, and Toxicologic Agents are essential categories of pharmaceutical APIs that address poisoning emergencies, deter harmful behaviors, and enable toxicological research. Their development and availability are crucial for safeguarding public health, enhancing patient care, and advancing our understanding of toxicology.
