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Lumefantrine co-artemether
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Looking for Lumefantrine co-artemether API 141204-94-6?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Lumefantrine co-artemether. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Lumefantrine co-artemether
- Synonyms:
- Artemether/lumefantrine , Lumefantrine co-artemether
- Cas Number:
- 141204-94-6
- DrugBank number:
- DB13085
- Unique Ingredient Identifier:
- 5T2U51A0MW
General Description:
Lumefantrine co-artemether, identified by CAS number 141204-94-6, is a notable compound with significant therapeutic applications. Lumefantrine Co-Artemether (Riamet) has been investigated for the treatment of Malaria, Malaria, Falciparum, Malaria in Pregnancy, Uncomplicated Malaria, and Uncomplicated Knowlesi Malaria. Lumefantrine Co-Artemether is a tablet formulation of artemether and lumefantrine, a well-tolerated, fast-acting and effective blood schizontocidal drug that serves primarily in the treatment of uncomplicated falciparum malaria that is resistant to other antimalarials. Artemether, an artemisinin derivative, has several proposed mechanisms of action, including interference with plasmodial transport proteins, interference with mitochondrial electron transport, and the production of free radicals to reduce blood antioxidants and glutathione. While artemether results in rapid defervescence, parasite clearance, and clinical improvement, it also has a relatively high recrudescence rate when used as monotherapy. The exact mechanism of action of lumefantrine is not well defined, but it is thought to inhibit -hematin formation, an important detoxification pathway for the parasite. Unlike artemether, lumefantrine has a slower onset of action, resulting in clearance of residual parasites and a decrease in recrudescence rate. The combination is an effective and well-tolerated malaria treatment, providing high cure rates even in areas of multi-drug resistance.
Lumefantrine co-artemether is a type of Antimalarial
The Antimalarial category of pharmaceutical APIs encompasses a range of active ingredients used in the development of drugs to treat and prevent malaria, a life-threatening infectious disease caused by the Plasmodium parasite. These APIs are crucial in formulating effective antimalarial medications.
One widely used API in this category is Artemisinin, derived from the Artemisia annua plant. It exhibits potent antimalarial properties and is a key component in various combination therapies. Another prominent API is Chloroquine, an aminoquinoline compound that has been historically used as a primary treatment for malaria. However, due to emerging drug resistance, alternative APIs like Mefloquine and Quinine have gained prominence.
These APIs work by interfering with the life cycle of the Plasmodium parasite. They inhibit various stages of parasite development, such as preventing the replication of the parasite's DNA and disrupting its metabolic processes. By targeting the parasite, antimalarial APIs help to control and eliminate the infection, reducing the severity of symptoms and preventing complications.
The development and production of high-quality antimalarial APIs require stringent quality control measures to ensure their safety and efficacy. Pharmaceutical companies adhere to strict regulations and guidelines to guarantee the purity, stability, and bioavailability of these APIs. Additionally, ongoing research aims to discover new antimalarial APIs and formulations to combat drug resistance and improve treatment outcomes.
In conclusion, the Antimalarial category of pharmaceutical APIs plays a vital role in the formulation of drugs used to treat and prevent malaria. These APIs, such as Artemisinin, Chloroquine, Mefloquine, and Quinine, effectively target the Plasmodium parasite, aiding in the management and eradication of malaria infections.
