Coal tar preparations
Coal tar preparations are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that are derived from coal tar, a dark, thick liquid produced during the carbonization of coal. These preparations contain various compounds, including phenols, polycyclic aromatic hydrocarbons (PAHs), and heterocyclic compounds, which give them their therapeutic properties.
Coal tar preparations have been used in medicine for decades due to their antipruritic (anti-itching), anti-inflammatory, and keratolytic (skin peeling) properties. They are commonly employed in the treatment of various skin conditions, such as psoriasis, eczema, and seborrheic dermatitis.
The key active ingredients in coal tar preparations, such as coal tar itself or its derivatives like anthralin and coal tar acids, exert their therapeutic effects through multiple mechanisms. They help reduce inflammation by inhibiting the release of inflammatory mediators and suppressing abnormal immune responses. Moreover, they slow down the proliferation of skin cells and promote their normal differentiation, which is crucial in the treatment of conditions characterized by excessive skin cell growth.
To ensure safety and efficacy, coal tar preparations undergo stringent quality control measures, including purification and standardization processes. They are formulated into various pharmaceutical forms, such as creams, ointments, lotions, and shampoos, to suit different patient needs and treatment requirements.
In conclusion, coal tar preparations are a valuable subcategory of pharmaceutical APIs widely used for the treatment of various skin conditions. Their diverse therapeutic properties and proven efficacy make them an important component of dermatological treatment regimens.
| Name | CAS number |
|---|---|
| Coal tar |