Cyclothiazide API Manufacturers
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Looking for Cyclothiazide API 2259-96-3?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Cyclothiazide. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Cyclothiazide
- Synonyms:
- Ciclotiazida , Ciclotiazide , Cyclothiazide , Cyclothiazidum
- Cas Number:
- 2259-96-3
- DrugBank number:
- DB00606
- Unique Ingredient Identifier:
- P71U09G5BW
About Cyclothiazide
Want to know more about Cyclothiazide? As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of cyclothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Cyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.
More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.
