Daclatasvir | compare suppliers & send inquiries for free
Looking for Daclatasvir 1009119-64-5?
Want to know what Daclatasvir is used for? Daclatasvir is a direct-acting antiviral agent against Hepatitis C Virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection. It is marketed under the name DAKLINZA and is contained in daily oral tablets as the hydrochloride salt form . Hepatitis C is an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients Daclatasvir was the first drug with demonstrated safety and therapeutic efficacy in treating HCV genotype 3 without the need for co-administration of interferon or Ribavirin.
It exerts its antiviral action by preventing RNA replication and virion assembly via binding to NS5A, a nonstructural phosphoprotein encoded by HCV. Binding to the N-terminus of the D1 domain of NS5A prevents its interaction with host cell proteins and membranes required for virion replication complex assembly. Daclatasvir is shown to target both the cis- and trans-acting functions of NS5A and disrupts the function of new HCV replication complexes by modulating the NS5A phosphorylation status The most common critical NS5A amino acid substitutions that led to reduced susceptibility to daclatasvir therapy occured at position Q30 (Q30H/K/R) and M28 in genotype 1a patients and Y93H in genotype 3 patients. According to 2017 American Association for the Study of Liver Diseases (AASLD), 60mg of daclatasvir is recommended with 400mg.
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Daclatasvir manufacturers | traders | suppliers
We have 11 companies offering Daclatasvir from 2 different countries.
Get in contact with the supplier of your choice:
- Apino Pharma Co., Ltd. from China
- Optimus Drugs Pvt Ltd from India
- Mylan from India
- Shaoxing Hantai Pharma from China
- Glenmark Pharma from India
- Hetero Labs from India
- Laurus Labs from India
- MSN Life Sciences from India
- Cipla from India
- Fuxing Long Rui Pharma from China
- Beijing Mesochem Technology Co Ltd from China
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