Dimethicone 410 API Manufacturers

General Description:

Dimethicone 410, identified by CAS number 9006-65-9, is a notable compound with significant therapeutic applications. Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products. It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit. It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%. The name dimethicone has a lot of nomenclature inconsistencies as it is used to refer to common names, generic names, trade names or even for the listing of mixtures. It is reported that the term dimethicone includes the notation of polydimethylsiloxane and trimethylsiloxy-terminated fluids between 20-30,000 cSt (viscosity).

Indications:

This drug is primarily indicated for: Dimethicone is approved as a transdermal drug delivery system. Dimethicone 410 is part of the simethicone element in Dow Corning Q7-2242 LVA which is an antifoam. Some OTC's containing dimethicone are used to relieve the discomfort of infant gas caused by air swallowing or certain formulas or food, to prevent and help rash, to protect and relieve chapped or cracked skin and as an anti-lice agent. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Metabolism:

Dimethicone 410 undergoes metabolic processing primarily in: Dimethicone 410 is not metabolized and it is excreted unchanged. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.

Absorption:

The absorption characteristics of Dimethicone 410 are crucial for its therapeutic efficacy: The use of dimethicone in skin moisturizers or anti-lice products have proven a very low absorption rate. Studies have indicated that approximately 0.5% of the dose applied to the skin could be considered as bioavailable. When given orally, as it is administered in anti-gas medications, dimethicone 410 is not absorbed or absorbed in very minimal quantities that account only for 0.001-0.2% of the administered dose. Therefore, a minimal to absent dimethicone form can be detected outside of the GI tract. The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Dimethicone 410 is an important consideration for its dosing schedule: As dimethicone is pharmacologically inert and it is not absorbed, pharmacokinetic studies regarding its half-life are not relevant. This determines the duration of action and helps in formulating effective dosing regimens.

Protein Binding:

Dimethicone 410 exhibits a strong affinity for binding with plasma proteins: Dimethicone 410 does not bind to plasma proteins as it is not absorbed. This property plays a key role in the drug's pharmacokinetics and distribution within the body.

Route of Elimination:

The elimination of Dimethicone 410 from the body primarily occurs through: In preclinical trials of skin preparations, dimethicone 410 was collected in trace levels in feces, expired air and subcutaneous swabs. When given orally, the entire dose of dimethicone can be found unchanged in feces and the recovery can account for even 99.6-99.8% of the administered dose. The limited absorbed dose can be found in urine as unchanged dimethicone. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.

Volume of Distribution:

Dimethicone 410 is distributed throughout the body with a volume of distribution of: As dimethicone is pharmacologically inert and it is not absorbed, pharmacokinetic studies regarding the volume of distribution are not relevant. This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Dimethicone 410 is a critical factor in determining its safe and effective dosage: A very minimal amount of dimethicone is excreted unchanged in urine. It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Dimethicone 410 exerts its therapeutic effects through: The activity of dimethicone as an anti-flatulent agent prevents the formation of mucus surrounding the gas pockets in the gastrointestinal tract. This allows the formation of big gas bubbles that can be expelled easily. Dimethicone is usually combined with an antacid to confirm the elimination of trapped gas. This particular combination is usually known as simethicone. The use of dimethicone 410 as an emollient and occlusive agent for the treatment of dry skin conditions has shown to prevent transepidermal water loss which translates into moisturizing of the dry or chapped skin. The effect of dimethicone also reduce flaking and acts as a lubricant which translates into the look of soft, smooth and flexible nature of healthy and young-looking skin. The use of dimethicone 410 as an anti-lice medication has been reported to effectively cause a lice mortality between 98-100% but the ovicidal effect seems to be limited. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Dimethicone 410 functions by: Dimethicone, as well as all silicone derivatives, is considered as an occlusive and emollient agent. All occlusive agents act physically blocking transepidermal water loss by the formation of a hydrophobic film on the skin surface and within the superficial interstitium between corneocytes. Simethicone is often combined in drug products with petrolatum, which makes it greasy. The emollient characteristic of dimethicone is performed by filling the space between skin flakes which smooths the skin. For its use as an anti-flatulent agent, dimethicone 410 acts as an antifoaming agent and it works by reducing the surface tension of gas bubbles. This causes the combination of the bubbles to form larger bubbles in the stomach which can pass easily by means of belching. The use of dimethicone 410 in anti-lice medication has not been fully elucidated but it seems to be related to the disruption of the water balance mechanism in the lice which leads to the rupture of the gut. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Toxicity:

Experimental Properties:

Further physical and chemical characteristics of Dimethicone 410 include:

• Water Solubility: Insoluble
• Boiling Point: >65ºC as a silicone fluid