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Ethylenediamine
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Looking for Ethylenediamine API 107-15-3?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Ethylenediamine. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Ethylenediamine
- Synonyms:
- 1,2-diaminoethane , Aethaldiamin , edamine , ethane-1,2-diamine , Ethyleendiamine , Ethylendiamine , Ethylene-diamine , Ethylenediamine
- Cas Number:
- 107-15-3
- DrugBank number:
- DB14189
- Unique Ingredient Identifier:
- 60V9STC53F
General Description:
Ethylenediamine, identified by CAS number 107-15-3, is a notable compound with significant therapeutic applications. Ethylenediamine is an organic compound that is used as a building block for the production of many other chemical products. It is also used as an excipient in many pharmacological preparations such as creams. Notably, ethylenediamine is a contact sensitizer capable of producing local and generalized reactions . Sensitivity to ethylenediamine may be identified with a clinical patch test.
Indications:
This drug is primarily indicated for: Ethylenediamine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Absorption:
The absorption characteristics of Ethylenediamine are crucial for its therapeutic efficacy: After oral administration its bioavailability is about 0.34, due to a substantial first-pass effect. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Ethylenediamine is an important consideration for its dosing schedule: Ethylenediamine has a short half life of ~0.55 hours . This determines the duration of action and helps in formulating effective dosing regimens.
Route of Elimination:
The elimination of Ethylenediamine from the body primarily occurs through: Renal excretion of the unchanged substance amounts to only about 18% after intravenous and 3% after oral administration. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Ethylenediamine is distributed throughout the body with a volume of distribution of: Vd = 0.133 l/kg. This metric indicates how extensively the drug permeates into body tissues.
Classification:
Ethylenediamine belongs to the class of organic compounds known as monoalkylamines. These are organic compounds containing an primary aliphatic amine group, classified under the direct parent group Monoalkylamines. This compound is a part of the Organic compounds, falling under the Organic nitrogen compounds superclass, and categorized within the Organonitrogen compounds class, specifically within the Amines subclass.
Categories:
Ethylenediamine is categorized under the following therapeutic classes: Allergens, Amines, Antigens, Biological Factors, Cell-mediated Immunity, Diamines, Increased Histamine Release, Polyamines, Standardized Chemical Allergen. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Ethylenediamine is a type of Dental and Oral Agents
Dental and oral agents belong to the pharmaceutical API category, playing a crucial role in oral health care. These agents are specifically designed to address various dental and oral conditions, ranging from tooth decay and gum diseases to oral infections and inflammation.
One of the primary types of dental and oral agents is antimicrobial APIs. These active pharmaceutical ingredients are known for their ability to inhibit the growth of bacteria and fungi in the oral cavity, helping to prevent and treat infections. Common antimicrobial APIs used in dental and oral care include chlorhexidine, cetylpyridinium chloride, and triclosan.
Another important category is analgesic APIs, which provide pain relief in dental and oral procedures. These agents work by blocking pain signals and reducing inflammation. Popular analgesic APIs in dental care include lidocaine, benzocaine, and ibuprofen.
Fluoride APIs are widely used in dental products to strengthen tooth enamel and prevent tooth decay. These APIs aid in remineralization, making teeth more resistant to acid attacks from bacteria and sugary foods.
Furthermore, there are APIs specifically formulated for treating specific oral conditions such as dry mouth or halitosis. These agents help restore moisture in the mouth and neutralize odor-causing compounds.
Dental and oral agents are typically formulated into various dosage forms, including mouthwashes, toothpaste, gels, and oral sprays. These formulations ensure convenient and effective delivery of the APIs to the affected areas in the oral cavity.
In summary, dental and oral agents are a vital component of oral health care, offering antimicrobial, analgesic, remineralizing, and specific therapeutic benefits. Incorporating these pharmaceutical APIs into dental products helps individuals maintain optimal oral health and prevent dental problems.
