Perboric acid API Manufacturers

General Description:

Perboric acid, identified by CAS number 14034-78-7, is a notable compound with significant therapeutic applications. Perboric acid is mainly found in its salt form of sodium perborate and it can be found as a monohydrate or tetrahydrate. It is one of the peroxy acid salts with very wide functionalities in industrial settings. Perboric acid in the form of sodium perborate is approved by Health Canada since 2004 to be used as a disinfectant of medical instruments. By the FDA, sodium perborate is approved as an ointment for the protection of poison ivy dermatitis.

Indications:

This drug is primarily indicated for: In the industry, sodium perborate is used as a disinfectant. It is also part of the ingredients for detergents, bleach powders, and personal care formulations. In cosmetic products, perboric acid and mainly its salt are used as an oxidizing agent for dyeing or permanent waving. In dentistry, sodium perborate monohydrate is used as an aid for the removal of phlegm, mucus or other secretions associated with an occasional sore in the mouth, for cleansing minor wounds, for temporary cleanse of canker sore or for the removal of foreign materials in minor wounds. In ophthalmic preparations, sodium perborate is used as a preservative for products used for dry eye. This use is approved as this compound rapidly degrades to harmless byproducts. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Metabolism:

Perboric acid undergoes metabolic processing primarily in: If perboric acid or its sodium salt get in touch with body fluids, they will rapidly dissociate into hydrogen peroxide, carbonate and sodium ions which are naturally present in the body. The produced hydrogen peroxide is rapidly degraded in blood and tissues. As carbonate is part of the normal buffer system of the body it is unlikely to be absorbed in amounts that could disturb the normal balance of the body. The rest of the dissociation products are also not thought to produce any significant systemic modifications. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.

Absorption:

The absorption characteristics of Perboric acid are crucial for its therapeutic efficacy: Dermal absorption is assumed to be very low due to the high hydrophilicity of perboric acid and its ionic nature. The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Perboric acid is an important consideration for its dosing schedule: As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of and . This determines the duration of action and helps in formulating effective dosing regimens.

Protein Binding:

Perboric acid exhibits a strong affinity for binding with plasma proteins: As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of and . This property plays a key role in the drug's pharmacokinetics and distribution within the body.

Route of Elimination:

The elimination of Perboric acid from the body primarily occurs through: As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of and . Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.

Volume of Distribution:

Perboric acid is distributed throughout the body with a volume of distribution of: As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of and . This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Perboric acid is a critical factor in determining its safe and effective dosage: As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of and .[. It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Perboric acid exerts its therapeutic effects through: No systemic effects are expected as it is highly unlikely that the substance will be systemically available. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Perboric acid functions by: Perboric acid acts as a source of active oxygen. In contact with water, perboric acid hydrolyzes to hydrogen and borate. As an antiseptic, the formation of hydrogen peroxide oxidizes the cellular components of the surrounding bacteria and kills them. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Toxicity:

Classification:

Perboric acid belongs to the class of inorganic compounds known as metalloid oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a metalloid, classified under the direct parent group Metalloid oxides. This compound is a part of the Inorganic compounds, falling under the Mixed metal/non-metal compounds superclass, and categorized within the Metalloid organides class, specifically within the Metalloid oxides subclass.

Categories:

Perboric acid is categorized under the following therapeutic classes: Acids, Alimentary Tract and Metabolism, Anions, Antiinfectives and Antiseptics for Local Oral Treatment, Boric Acids, Boron Compounds, Electrolytes, Ions, Stomatological Preparations, Tooth Bleaching. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.

Experimental Properties:

Further physical and chemical characteristics of Perboric acid include:

• Water Solubility: 23 g/L
• Melting Point: 63 ºC but decomposes at 60 ºC
• Boiling Point: 130-150 ºC but decomposes at 60 ºC