Calcium lactate API Manufacturers
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Looking for Calcium lactate API 814-80-2?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Calcium lactate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Calcium lactate
- Synonyms:
- 2-Hydroxypropanoic acid calcium salt , Calcio lactato , Calcium 2-hydroxypropanoate (1:2) , Calcium dilactate , Hemicalcium L-lactate
- Cas Number:
- 814-80-2
- DrugBank number:
- DB13231
- Unique Ingredient Identifier:
- 2URQ2N32W3
General Description:
Calcium lactate, identified by CAS number 814-80-2, is a notable compound with significant therapeutic applications. Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Indications:
This drug is primarily indicated for: Indicated for use as the nutritional supplement. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Calcium lactate undergoes metabolic processing primarily in: In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle . This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Calcium lactate are crucial for its therapeutic efficacy: In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins . The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport . The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Calcium lactate is an important consideration for its dosing schedule: No pharmacokinetic data available. This determines the duration of action and helps in formulating effective dosing regimens.
Protein Binding:
Calcium lactate exhibits a strong affinity for binding with plasma proteins: No pharmacokinetic data available. This property plays a key role in the drug's pharmacokinetics and distribution within the body.
Route of Elimination:
The elimination of Calcium lactate from the body primarily occurs through: Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours . Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Calcium lactate is distributed throughout the body with a volume of distribution of: The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity . This metric indicates how extensively the drug permeates into body tissues.
Clearance:
The clearance rate of Calcium lactate is a critical factor in determining its safe and effective dosage: No pharmacokinetic data available. It reflects the efficiency with which the drug is removed from the systemic circulation.
Pharmacodynamics:
Calcium lactate exerts its therapeutic effects through: Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively . The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Calcium lactate functions by: In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways . Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis . This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Toxicity:
Classification:
Calcium lactate belongs to the class of organic compounds known as carboxylic acid salts. These are ionic derivatives of carboxylic acid, classified under the direct parent group Carboxylic acid salts. This compound is a part of the Organic compounds, falling under the Organic acids and derivatives superclass, and categorized within the Carboxylic acids and derivatives class, specifically within the Carboxylic acid derivatives subclass.
Categories:
Calcium lactate is categorized under the following therapeutic classes: Alimentary Tract and Metabolism, Calcium Salts, Hydroxy Acids, Mineral Supplements. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Calcium lactate include:
- Water Solubility: 48 g/L
- Melting Point: > 120
Calcium lactate is a type of Electrolytes
Electrolytes are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) that play a vital role in maintaining the balance of essential ions in the body. These ions include sodium, potassium, calcium, magnesium, and chloride, among others. Electrolytes are responsible for maintaining proper hydration, regulating nerve and muscle function, and supporting various physiological processes.
In the pharmaceutical industry, electrolytes are widely utilized in the formulation of oral rehydration solutions, intravenous fluids, and dialysis solutions. These medications are employed to treat conditions such as dehydration, electrolyte imbalances, and renal dysfunction.
The availability of high-quality electrolyte APIs is of utmost importance to ensure the efficacy and safety of these pharmaceutical products. Pharmaceutical manufacturers rely on reputable suppliers who adhere to stringent quality control measures and comply with Good Manufacturing Practices (GMP) to produce electrolyte APIs of consistent quality.
To meet regulatory requirements, electrolyte APIs undergo rigorous testing to confirm their identity, purity, and potency. This includes analysis using advanced techniques such as high-performance liquid chromatography (HPLC), mass spectrometry (MS), and atomic absorption spectroscopy (AAS).
In conclusion, electrolytes are a vital category of pharmaceutical APIs used to maintain the balance of essential ions in the body. They are extensively employed in various medications aimed at treating dehydration, electrolyte imbalances, and renal dysfunction. Pharmaceutical manufacturers prioritize the use of high-quality electrolyte APIs to ensure the safety and efficacy of their products, and adherence to stringent regulatory standards is crucial in their production and testing processes.
