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Bimoclomol
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Looking for Bimoclomol API 130493-03-7?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Bimoclomol. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Bimoclomol
- Synonyms:
- Cas Number:
- 130493-03-7
- DrugBank number:
- DB06258
- Unique Ingredient Identifier:
- 9IYF14814M
General Description:
Bimoclomol, identified by CAS number 130493-03-7, is a notable compound with significant therapeutic applications. Bimoclomol is an investigational drug that induces stress proteins and has cytoprotective effects.
Indications:
This drug is primarily indicated for: Investigated for use/treatment in neuropathy (diabetic) and wounds. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Mechanism of Action:
Bimoclomol functions by: Bimoclomol binds to HSF-1 and induces a prolonged binding of HSF-1 to the respective DNA elements. Since HSF-1 does not bind to DNA in the absence of stress, the bimoclomol-induced extension of HSF-1/DNA interaction may contribute to the chaperone co-induction of bimoclomol observed previously. These findings indicate that bimoclomol may be of value in targeting HSF-1 so as to induce up-regulation of protective Hsp-s in a non-stressful manner and for therapeutic benefit. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Bimoclomol belongs to the class of organic compounds known as pyridines and derivatives. These are compounds containing a pyridine ring, which is a six-member aromatic heterocycle which consists of one nitrogen atom and five carbon atoms, classified under the direct parent group Pyridines and derivatives. This compound is a part of the Organic compounds, falling under the Organoheterocyclic compounds superclass, and categorized within the Pyridines and derivatives class, specifically within the None subclass.
Bimoclomol is a type of Emollients and protectives
Emollients and protectives are an essential category of pharmaceutical Active Pharmaceutical Ingredients (APIs) used in various topical formulations. These substances play a crucial role in protecting and moisturizing the skin, making them widely utilized in the pharmaceutical and cosmetic industries.
Emollients are substances that help restore and maintain the skin's natural moisture barrier, preventing water loss and promoting hydration. They act by forming a thin film on the skin's surface, reducing transepidermal water loss (TEWL) and improving the skin's texture and elasticity. Common emollients include natural oils, such as jojoba oil, almond oil, and shea butter, as well as synthetic compounds like mineral oil and petrolatum.
Protectives, on the other hand, are API ingredients that shield the skin from harmful external factors, such as irritants, allergens, and environmental pollutants. They create a physical barrier that prevents the penetration of harmful substances into the skin. Protectives are often combined with emollients to provide a dual function of hydration and protection.
The applications of emollients and protectives are vast and encompass a wide range of pharmaceutical and cosmetic products. They are commonly found in moisturizers, creams, lotions, ointments, balms, and sunscreens. These APIs are especially beneficial for individuals with dry or sensitive skin, as they can soothe irritation, reduce redness, and alleviate discomfort.
In conclusion, emollients and protectives are vital categories of pharmaceutical APIs that provide hydration and protection to the skin. Their versatile applications make them crucial ingredients in a wide array of topical formulations, contributing to the overall health and well-being of the skin.
