Olesoxime API Manufacturers
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Looking for Olesoxime API 22033-87-0?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Olesoxime. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Olesoxime
- Synonyms:
- (EZ)-N-(CHOLEST-4-EN-3-YLIDENE)HYDROXYLAMINE , 4-Cholesten-3-one, oxime , cholest-4-en-3-one, oxime
- Cas Number:
- 22033-87-0
- DrugBank number:
- DB05185
- Unique Ingredient Identifier:
- 8V8EF6094N
General Description:
Olesoxime, identified by CAS number 22033-87-0, is a notable compound with significant therapeutic applications. Olesoxime is a cholesterol-like small molecule that has demonstrated a remarkable neuroprotective profile in a battery of both in vitro and in vivo preclinical models. For example, it has demonstrated the ability to prevent neurodegeneration, enhance nerve function and accelerate neuroregeneration following nerve trauma.
Indications:
This drug is primarily indicated for: Investigated for use/treatment in neurologic disorders. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Mechanism of Action:
Olesoxime functions by: Olesoxime interacts with a physiologically relevant target: the mitochondrial permeability transition pore (mPTP). Mitochondria are central mediators of cell death and are implicated in most if not all neurodegenerative diseases regardless of the initiating factor: genetic mutations, excitotoxicity, reactive oxygen species, ischemia, chemical toxicity, etc. Mitochondria play diverse roles in all cells. In neurons, especially near synaptic sites, mitochondria are essential calcium-buffering organelles in areas where membrane excitability leads to large influx of calcium through calcium channels. Mitochondria also produce the ATP necessary for microtubule-based axoplasmic transport and maintaining the activity of ion and nutrient transporters. If a neuron fails to establish or maintain its functional role, mitochondria are responsible for eliminating it by releasing apoptotic factors. Olesoxime, by interacting with protein components of the mPTP, prevents the release of these apoptotic factors and therefore protects the neuron. This mechanism of action may lead to a general neuroprotective activity with utility in other therapeutic indications. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Categories:
Olesoxime is categorized under the following therapeutic classes: Cholestanes, Cholestenes, Fused-Ring Compounds, Steroids. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Olesoxime is a type of Emollients and protectives
Emollients and protectives are an essential category of pharmaceutical Active Pharmaceutical Ingredients (APIs) used in various topical formulations. These substances play a crucial role in protecting and moisturizing the skin, making them widely utilized in the pharmaceutical and cosmetic industries.
Emollients are substances that help restore and maintain the skin's natural moisture barrier, preventing water loss and promoting hydration. They act by forming a thin film on the skin's surface, reducing transepidermal water loss (TEWL) and improving the skin's texture and elasticity. Common emollients include natural oils, such as jojoba oil, almond oil, and shea butter, as well as synthetic compounds like mineral oil and petrolatum.
Protectives, on the other hand, are API ingredients that shield the skin from harmful external factors, such as irritants, allergens, and environmental pollutants. They create a physical barrier that prevents the penetration of harmful substances into the skin. Protectives are often combined with emollients to provide a dual function of hydration and protection.
The applications of emollients and protectives are vast and encompass a wide range of pharmaceutical and cosmetic products. They are commonly found in moisturizers, creams, lotions, ointments, balms, and sunscreens. These APIs are especially beneficial for individuals with dry or sensitive skin, as they can soothe irritation, reduce redness, and alleviate discomfort.
In conclusion, emollients and protectives are vital categories of pharmaceutical APIs that provide hydration and protection to the skin. Their versatile applications make them crucial ingredients in a wide array of topical formulations, contributing to the overall health and well-being of the skin.
