Follitropin beta API Manufacturers
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Looking for Follitropin beta API 9002-68-0?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Follitropin beta. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Follitropin beta
- Synonyms:
- Follicle stimulating hormone beta , Follitrophin beta , Follitropin beta , Follitropin beta chain precursor , FSH-b , FSH-B , FSH-beta
- Cas Number:
- 9002-68-0
- DrugBank number:
- DB00066
- Unique Ingredient Identifier:
- 8FYM5179QJ
About Follitropin beta
Learn more about Follitropin. Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn Follitropin beta is produced in genetically engineered Chinese hamster cell lines (CHO).
The nomenclature “beta” differentiates it from another recombinant human FSH product that was marketed earlier as follitropin alpha. Follitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. However, a more recent study showed there is may be a slight clinical difference, with the alpha form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH.
Check who is selling Follitropin in the overview above.
