Gemtuzumab ozogamicin API Manufacturers
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Looking for Gemtuzumab ozogamicin API 220578-59-6?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Gemtuzumab ozogamicin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Gemtuzumab ozogamicin
- Cas Number:
- 220578-59-6
- DrugBank number:
- DB00056
- Unique Ingredient Identifier:
- 8GZG754X6M
About Gemtuzumab ozogamicin
Why are professionals looking for Gemtuzumab ozogamicin? Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheamicin per mole of antibody. The antibody is specifically directed against the CD33 antigen present on leukemic myeloblasts in most patients with acute myeloid leukemia (AML).
By binding to the CD33 antigen on tumors, the cytotoxic agent blocks the growth of cancerous cells and causes cell death. Marketing approval of gemtuzumab ozogamicin was granted on May 2000 by FDA as a treatment for patients with CD33-positive AML in first relapse who are 60 years of age or older and who are not considered candidates for cytotoxic chemotherapy.
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