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Looking for Ivabradine 155974-00-8?
Here, you can find what Ivabradine is used for, in short. Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus rhythm with resting heart rate ≥70 beats per minute, who are not on beta-blockers due to contraindications or already receiving maximum beta-blocker dose. Recently a new indication was added to treat symptomatic heart failure from dilated cardiomyopathy for patients 6 months or more in age.
Ivabradine acts by selectively inhibiting the funny channel pacemaker current (If) in the sinoatrial node in a dose-dependent fashion, resulting in a lower heart rate and thus more blood to flow to the myocardium. Although non-dihydropyridine calcium channel blockers and beta blockers also effectively lower heart rate, they exhibit adverse events due to their negative ionotropic effects. Therefore, as ivabradine is designed as a pure heart rate-lowering drug by selectively acting on the If channels, it may offer a more favorable side effect profile due to its lower likelihood of causing serious adverse effects.
More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.
Ivabradine manufacturers | traders | suppliers
We have 21 companies offering Ivabradine from 3 different countries.
Get in contact with the supplier of your choice:
- Amuna Pharmaceuticals from India
- Shandong Octagon Chemicals Limited from China
- Chemicea Pharmaceuticals Pvt Ltd from India
- TIEFENBACHER API + Ingredients from Germany
- JINLAN Pharm-Drugs Technology Co., Ltd. from China
- Hetero Drugs from India
- Ind-Swift Labs. from India
- Metrochem API from India
- Menovo from China
- Kores from India
- Biocon from India
- Shaoxing Hantai Pharma from China
- Alembic Pharma from India
- Cadila Healthcare from India
- Beijing Huikang Boyuan from China
- Fuxing Long Rui Pharma from China
- Maithri Labs. from India
- Jiangsu Hengrui from China
- Jiangsu Yutian Pharmaceutical Co Ltd from China
- Beijing Lunarsun Pharma from China
- Utopharm (Shanghai) Company Limited from China
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