Metreleptin API Manufacturers
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Looking for Metreleptin API 186018-45-1?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Metreleptin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Metreleptin
- Synonyms:
- Metreleptina , Metreleptin , Metreleptinum , N-Methionylleptin , r-metHuLeptin
- Cas Number:
- 186018-45-1
- DrugBank number:
- DB09046
- Unique Ingredient Identifier:
- TL60C27RLH
About Metreleptin
It's time for some technical information for the ones who understand chemistry: Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with congenital or acquired lipodystrophy. Affecting less than 500 people worldwide, lipodystrophy is characterized by a lack of adipose tissue, fat deposition in the muscles and liver, and metabolic complications such as hypertriglyceridemia, insulin resistance, diabetes mellitus, and fatty liver disease. These metabolic abnormalities are often aggravated by excessive food intake, which is further aggravated by leptin deficiency, a protein secreted by adipose tissue. Administration of Metreleptin results in improvement of metabolic symptoms including improvements in insulin resistance, reduced HbA1c and fasting glucose, reduced triglycerides, and reductions in food intake.
Metreleptin is produced in E. coli and differs from native human leptin by the addition of a methionine residue at its amino terminus. It is administered as a once daily subcutaneous injection. On Feb. 24, 2014, Metreleptin was approved by the FDA for the treatment of complications of leptin deficiency, in addition to diet, in patients with congenital generalized or acquired generalized lipodystrophy. Metreleptin is marketed under the brand Myalept® by Aegerion Pharmaceuticals, Inc.
You can ask the supplier about all relevant certificates for the product such as CoA, Safety Data Sheet and DMF.
