Oprelvekin API Manufacturers
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Looking for Oprelvekin API 145941-26-0?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Oprelvekin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Oprelvekin
- Synonyms:
- Adipogenesis inhibitory factor , AGIF , IL-11 , Interleukin-11 precursor
- Cas Number:
- 145941-26-0
- DrugBank number:
- DB00038
- Unique Ingredient Identifier:
- HM5641GA6F
About Oprelvekin
What can you use it for? Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced in Escherichia coli (E. coli) by recombinant DNA technology. With a molecular mass of approximately000 daltons, the non-glycosylated protein is 177 amino acids in length in comparison to the natural IL- which is 178 amino acid long. However, it displays comparable biological activity compared to the natural IL-11 in vitro and in vivo.
Oprelvekin works by stimulating megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies of animals with moderate and severe myelosuppression, in addition to compromised hematopoiesis, oprelvekin was shown to potently induce thrombopoiesis and improve platelet nadirs and accelerated platelet recoveries compared to controls. In animal studies, oprelvekin was also shown to regulate intestinal epithelium growth by enhancing healing of gastrointestinal lesions, inhibit adiopegenesis and macrophageal released pro-inflammatory cytokines, and induce acute phase protein synthesis.
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