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Cobamamide
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Looking for Cobamamide API 13870-90-1?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Cobamamide. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Cobamamide
- Synonyms:
- (5,6-Dimethylbenzimidazolyl)cobamide coenzyme , 5'-Deoxy-5'-adenosylcobalamin , Adenosylcob(III)alamin , Adenosylcobalamin , cobamamida , cobamamidum , Cobanamida , Coenzyme B-12 , Coenzyme B12 , Vitamin B12 coenzyme
- Cas Number:
- 13870-90-1
- DrugBank number:
- DB11191
- Unique Ingredient Identifier:
- F0R1QK73KB
General Description:
Cobamamide, identified by CAS number 13870-90-1, is a notable compound with significant therapeutic applications. Cobamamide is one of the active forms of vitamin B12 that is also known as _adenosylcobalamin_ or _dibencozide_. This drug is available as a nutritional supplement to prevent vitamin B12 deficiency. Vitamin B12 is a collective term for these variously substituted corrinoids. The principal biochemical participants are two coenzyme forms of Vitamin B12 that are produced and activated in two separate cellular compartments: methylcobalamin in the cytosol and adenosylcobalamin in the mitochondria . Vitamin B12 (cyancobalamin, Cbl) has two active co-enzyme forms, _methylcobalamin (MeCbl)_ and _adenosylcobalamin (AdCbl)_. There has been a shift in the treatment of vitamin B12 deficiency such that MeCbl is being extensively used and promoted. This exists despite the fact that both MeCbl and AdCbl are necessary for life and have vastly different metabolic fates and functions. MeCbl is mainly involved along with folate in hematopoiesis and the growth of the brain during childhood. Deficiency of AdCbl disturbs the carbohydrate, fat and amino-acid metabolism, and therefore interferes with the formation of myelin. It is therefore important to treat vitamin B12 deficiency with a combination of MeCbl and AdCbl or hydroxocobalamin or cobalamin . Vitamin B12 has important physiological roles including DNA synthesis, myelin formation in the nervous system, red blood cell formation, as well as fatty acid and amino acid metabolism . Please refer to the entry for more information on this entry.
Toxicity:
Classification:
Cobamamide belongs to the class of organic compounds known as cobalamin derivatives. These are organic compounds containing a corrin ring, a cobalt atom, an a nucleotide moiety. Cobalamin Derivatives are actually derived from vitamin B12, classified under the direct parent group Cobalamin derivatives. This compound is a part of the Organic compounds, falling under the Organoheterocyclic compounds superclass, and categorized within the Tetrapyrroles and derivatives class, specifically within the Corrinoids subclass.
Categories:
Cobamamide is categorized under the following therapeutic classes: Antianemic Preparations, Blood and Blood Forming Organs, Coenzymes, Corrinoids, Enzymes and Coenzymes, Heterocyclic Compounds, Fused-Ring, Vitamin B Complex, Vitamin B12 and Folic Acid, Vitamins. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Cobamamide include:
- Water Solubility: partly miscible in water
Cobamamide is a type of Other substances
The pharmaceutical industry encompasses a diverse range of active pharmaceutical ingredients (APIs) that are used in the production of various medications. One category of APIs is known as other substances. This category includes substances that do not fall under the conventional classifications such as antibiotics, analgesics, or antihypertensives.
Other substances in pharmaceutical APIs consist of a broad array of chemical compounds with unique properties and applications. These substances play a crucial role in the formulation and development of specialized medications, catering to specific therapeutic needs. The category encompasses various substances like excipients, solvents, stabilizers, and pH adjusters.
Excipients are inert substances that aid in the manufacturing process and enhance the stability, bioavailability, and patient acceptability of pharmaceutical formulations. Solvents are used to dissolve other ingredients and facilitate their incorporation into the final product. Stabilizers ensure the integrity and shelf life of medications by preventing degradation or chemical changes. pH adjusters help maintain the desired pH level of a formulation, which can influence the drug's efficacy and stability.
Pharmaceutical manufacturers carefully select and incorporate specific other substances into their formulations, adhering to regulatory guidelines and quality standards. These substances undergo rigorous testing and evaluation to ensure their safety, efficacy, and compatibility with the desired pharmaceutical product. By employing other substances in API formulations, pharmaceutical companies can optimize drug delivery, improve patient compliance, and enhance therapeutic outcomes.
In summary, the other substances category of pharmaceutical APIs comprises a diverse range of chemicals, including excipients, solvents, stabilizers, and pH adjusters. These substances contribute to the formulation, stability, and performance of medications, enabling pharmaceutical manufacturers to develop specialized products that meet specific therapeutic requirements.
