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General Description:

Fibrinogen human, identified by CAS number 9001-32-5, is a notable compound with significant therapeutic applications. Fibrinogen concentrate (human) is a hematological agent. It works by replacing a certain protein in the blood that helps with blood clotting. Fibrinogen (factor I) is a soluble plasma glycoprotein with a molecular weight of about 340 kDa. It is a physiological substrate for three enzymes: plasmin, factor XIIIa and thrombin. It is indicated for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia.

Indications:

This drug is primarily indicated for: Human fibrinogen is used for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia. In combination with thrombin, it is used indicated as an adjunct to hemostasis for mild to moderate bleeding in adults undergoing surgery when control of bleeding by standard surgical techniques (such as suture, ligature, and cautery) is ineffective or impractical. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Absorption:

The absorption characteristics of Fibrinogen human are crucial for its therapeutic efficacy: Cmax is 140 mg/dL. The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Fibrinogen human is an important consideration for its dosing schedule: 78.7 hours. This determines the duration of action and helps in formulating effective dosing regimens.

Volume of Distribution:

Fibrinogen human is distributed throughout the body with a volume of distribution of: Mean volume of distribution is 52.7 mL/kg. This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Fibrinogen human is a critical factor in determining its safe and effective dosage: 0.59 mL/h/kg. It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Fibrinogen human exerts its therapeutic effects through: Fibrinogen replaces the missing, or low coagulation factor. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Fibrinogen human functions by: Fibrinogen (factor I) is a soluble plasma glycoprotein with a molecular weight of about 340 kDa. The native molecule is a dimer and consists of three pairs of polypeptide chains (Aα, Bβ and γ). Fibrinogen is a physiological substrate of three enzymes: thrombin, factor XIIIa, and plasmin. During the coagulation process, thrombin cleaves the Aα and Bβ chains releasing fibrinopeptides A and B (FPA and FPB, respectively). FPA is separated rapidly and the remaining molecule is a soluble fibrin monomer (fibrin I). The slower removal of FPB results in formation of fibrin II that is capable of polymerization that occurs by aggregation of fibrin monomers. The resulting fibrin is stabilized in the presence of calcium ions and by activated factor XIII, which acts as a transglutaminase. Factor XIIIa-induced cross-linking of fibrin polymers renders the fibrin clot more elastic and more resistant to fibrinolysis. Cross-linked fibrin is the end result of the coagulation cascade, and provides tensile strength to a primary hemostatic platelet plug and structure to the vessel wall. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Classification:

Fibrinogen human belongs to the None, classified under the direct parent group Peptides. This compound is a part of the Organic Compounds, falling under the Organic Acids superclass, and categorized within the Carboxylic Acids and Derivatives class, specifically within the Amino Acids, Peptides, and Analogues subclass.

Categories:

Fibrinogen human is categorized under the following therapeutic classes: Acute-Phase Proteins, Amino Acids, Peptides, and Proteins, Biological Factors, Blood and Blood Forming Organs, Blood Coagulation Factors, Blood Proteins, Fibrinogen, Hemostatics, Increased Coagulation Activity, Protein Precursors, Proteins. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.