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Hemoglobin
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Looking for Hemoglobin API 9008-02-0?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Hemoglobin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Hemoglobin
- Synonyms:
- Deoxyhemoglobin , Haemoglobin , Human hemoglobin
- Cas Number:
- 9008-02-0
- DrugBank number:
- DB04945
- Unique Ingredient Identifier:
- VSU9IB86SP
General Description:
Hemoglobin, identified by CAS number 9008-02-0, is a notable compound with significant therapeutic applications. The respiratory protein of the red blood cells. It consists primarily of globin and heme.
Indications:
This drug is primarily indicated for: Investigated for use/treatment in blood (blood forming organ disorders, unspecified) and hemorrhage. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Hemoglobin undergoes metabolic processing primarily in: There is a group of genetic disorders, known as the porphyrias that are characterized by errors in metabolic pathways of heme synthesis. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Protein Binding:
Hemoglobin exhibits a strong affinity for binding with plasma proteins: This means that the oxygen binding curve for fetal hemoglobin is left-shifted (i.e, a higher percentage of hemoglobin has oxygen bound to it at lower oxygen tension), in comparison to that of adult hemoglobin. This property plays a key role in the drug's pharmacokinetics and distribution within the body.
Mechanism of Action:
Hemoglobin functions by: A heme group is made up of iron (Fe) ion (charged atom) located in a heterocyclic ring, which is also called a porphyrin ring. The site of oxygen binding, the iron ion, binds with the nitrogens located in the center of the porphyrin ring. The iron ion binds with high affinity to the globular protein through the imidazole ring of the F8 residue on histidine which is found below the porphyrin ring. A sixth position can bind reversibly to oxygen, completing the formation of the octahedral group. One oxygen atom binds Fe and the other is found to protrude at an angle. When oxygen is not bound to Fe, a water molecule (weakly bound) fills the site, producing a distorted shape, often described as an octahedron. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Hemoglobin belongs to the None, classified under the direct parent group Peptides. This compound is a part of the Organic Compounds, falling under the Organic Acids superclass, and categorized within the Carboxylic Acids and Derivatives class, specifically within the Amino Acids, Peptides, and Analogues subclass.
Categories:
Hemoglobin is categorized under the following therapeutic classes: Amino Acids, Peptides, and Proteins, Blood Proteins, Globins, Hemeproteins, Hemoglobins, Proteins. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Hemoglobin is a type of Other substances
The pharmaceutical industry encompasses a diverse range of active pharmaceutical ingredients (APIs) that are used in the production of various medications. One category of APIs is known as other substances. This category includes substances that do not fall under the conventional classifications such as antibiotics, analgesics, or antihypertensives.
Other substances in pharmaceutical APIs consist of a broad array of chemical compounds with unique properties and applications. These substances play a crucial role in the formulation and development of specialized medications, catering to specific therapeutic needs. The category encompasses various substances like excipients, solvents, stabilizers, and pH adjusters.
Excipients are inert substances that aid in the manufacturing process and enhance the stability, bioavailability, and patient acceptability of pharmaceutical formulations. Solvents are used to dissolve other ingredients and facilitate their incorporation into the final product. Stabilizers ensure the integrity and shelf life of medications by preventing degradation or chemical changes. pH adjusters help maintain the desired pH level of a formulation, which can influence the drug's efficacy and stability.
Pharmaceutical manufacturers carefully select and incorporate specific other substances into their formulations, adhering to regulatory guidelines and quality standards. These substances undergo rigorous testing and evaluation to ensure their safety, efficacy, and compatibility with the desired pharmaceutical product. By employing other substances in API formulations, pharmaceutical companies can optimize drug delivery, improve patient compliance, and enhance therapeutic outcomes.
In summary, the other substances category of pharmaceutical APIs comprises a diverse range of chemicals, including excipients, solvents, stabilizers, and pH adjusters. These substances contribute to the formulation, stability, and performance of medications, enabling pharmaceutical manufacturers to develop specialized products that meet specific therapeutic requirements.
