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Ioflupane I-123
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Looking for Ioflupane I-123 API 155798-07-5?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Ioflupane I-123. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Ioflupane I-123
- Synonyms:
- 123I-FP-CIT , 123I-Ioflupane , Iodine ioflupane (123I) , Ioflupane ((123)I) , Ioflupane (123I) , Ioflupane I 123 , Ioflupane I(123) , Ioflupano (123I) , Ioflupanum (123I)
- Cas Number:
- 155798-07-5
- DrugBank number:
- DB08824
- Unique Ingredient Identifier:
- 3MM99T8R5Q
General Description:
Ioflupane I-123, identified by CAS number 155798-07-5, is a notable compound with significant therapeutic applications. Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes.
Indications:
This drug is primarily indicated for: Ioflupane I-123 is a SPECT (single photon emission computerized tomography) agent used to distinguish between Parkinson’s syndrome tremors and essential tremor. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Absorption:
The absorption characteristics of Ioflupane I-123 are crucial for its therapeutic efficacy: Absorption is 100% because administered I.V. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Ioflupane I-123 is an important consideration for its dosing schedule: Half life is 13.2 hours. This determines the duration of action and helps in formulating effective dosing regimens.
Route of Elimination:
The elimination of Ioflupane I-123 from the body primarily occurs through: About 60% is excreted in the urine and 14% in the feces after 48 hours. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Ioflupane I-123 is distributed throughout the body with a volume of distribution of: Compared to the entire brain, about 30% of radioactivity is taken up by the striatum. This metric indicates how extensively the drug permeates into body tissues.
Pharmacodynamics:
Ioflupane I-123 exerts its therapeutic effects through: iodine-123 labeled ioflupanebinds selectively to striatal presynaptic dopamine neurons by binding reversibly to presynaptic dopamine transporters. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Ioflupane I-123 functions by: Iodine-123 labeled ioflupane binds to presynaptic dopamine transporters. When Iodine-123 decays, a gammay ray is emmitted and detected through SPECT. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Ioflupane I-123 belongs to the class of organic compounds known as phenyltropanes. These are compounds containing a phenyl group linked to a tropane moiety. Tropane is an organonitrogenous [3.2.1] bicyclic organic compound, classified under the direct parent group Phenyltropanes. This compound is a part of the Organic compounds, falling under the Alkaloids and derivatives superclass, and categorized within the Tropane alkaloids class, specifically within the Phenyltropanes subclass.
Categories:
Ioflupane I-123 is categorized under the following therapeutic classes: Alkaloids, Aza Compounds, Azabicyclo Compounds, Central Nervous System, Diagnostic Radiopharmaceuticals, Diagnostic Uses of Chemicals, Drugs that are Mainly Renally Excreted, Iodine (123I) Compounds, Iodine Radioisotopes, Radioactive Diagnostic Agent, Radiopharmaceutical Activity, Tropanes. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Ioflupane I-123 include:
- Water Solubility: Soluble in water
- Melting Point: 82-83
Ioflupane I-123 is a type of Other substances
The pharmaceutical industry encompasses a diverse range of active pharmaceutical ingredients (APIs) that are used in the production of various medications. One category of APIs is known as other substances. This category includes substances that do not fall under the conventional classifications such as antibiotics, analgesics, or antihypertensives.
Other substances in pharmaceutical APIs consist of a broad array of chemical compounds with unique properties and applications. These substances play a crucial role in the formulation and development of specialized medications, catering to specific therapeutic needs. The category encompasses various substances like excipients, solvents, stabilizers, and pH adjusters.
Excipients are inert substances that aid in the manufacturing process and enhance the stability, bioavailability, and patient acceptability of pharmaceutical formulations. Solvents are used to dissolve other ingredients and facilitate their incorporation into the final product. Stabilizers ensure the integrity and shelf life of medications by preventing degradation or chemical changes. pH adjusters help maintain the desired pH level of a formulation, which can influence the drug's efficacy and stability.
Pharmaceutical manufacturers carefully select and incorporate specific other substances into their formulations, adhering to regulatory guidelines and quality standards. These substances undergo rigorous testing and evaluation to ensure their safety, efficacy, and compatibility with the desired pharmaceutical product. By employing other substances in API formulations, pharmaceutical companies can optimize drug delivery, improve patient compliance, and enhance therapeutic outcomes.
In summary, the other substances category of pharmaceutical APIs comprises a diverse range of chemicals, including excipients, solvents, stabilizers, and pH adjusters. These substances contribute to the formulation, stability, and performance of medications, enabling pharmaceutical manufacturers to develop specialized products that meet specific therapeutic requirements.
