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Meradimate
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Looking for Meradimate API 134-09-8?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Meradimate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Meradimate
- Synonyms:
- Menthyl anthranilate , Menthyl-O-aminobenzoate , Meradimate
- Cas Number:
- 134-09-8
- DrugBank number:
- DB11096
- Unique Ingredient Identifier:
- J9QGD60OUZ
General Description:
Meradimate, identified by CAS number 134-09-8, is a notable compound with significant therapeutic applications. Meradimate, before known as menthyl anthranilate, is used in a maximal concentration of 5% in different products as a UV filter. It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products.
Indications:
This drug is primarily indicated for: Meradimate is used as an active ingredient in sunscreens or as a sunblock factor in different products. It fits under the category of broad-spectrum absorbent agent. These characteristics are important to consider due to the fact that this kind of ingredients can either absorb or reflect UV radiation. It is also important to know the type of rays that cover. UVA rays are the responsible of causing sun damage and reaching deeper layers of the skin while UVB can only cause sunburn in the outer layer of the skin. When an agent is of broad spectrum, this means that this agent is capable of acting in both UVA and UVB rays. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Meradimate undergoes metabolic processing primarily in: As meradimate is not absorbed, this pharmacokinetic property is not relevant. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Meradimate are crucial for its therapeutic efficacy: Meradimate is not absorbed through the skin. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Meradimate is an important consideration for its dosing schedule: As meradimate is not absorbed, this pharmacokinetic property is not relevant. This determines the duration of action and helps in formulating effective dosing regimens.
Protein Binding:
Meradimate exhibits a strong affinity for binding with plasma proteins: As meradimate is not absorbed, this pharmacokinetic property is not relevant. This property plays a key role in the drug's pharmacokinetics and distribution within the body.
Route of Elimination:
The elimination of Meradimate from the body primarily occurs through: As meradimate is not absorbed, this pharmacokinetic property is not relevant. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Meradimate is distributed throughout the body with a volume of distribution of: As meradimate is not absorbed, this pharmacokinetic property is not relevant. This metric indicates how extensively the drug permeates into body tissues.
Clearance:
The clearance rate of Meradimate is a critical factor in determining its safe and effective dosage: As meradimate is not absorbed, this pharmacokinetic property is not relevant. It reflects the efficiency with which the drug is removed from the systemic circulation.
Pharmacodynamics:
Meradimate exerts its therapeutic effects through: Meradimate effect provides a low-level, broad-spectrum protecting coverage effect. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Meradimate functions by: Meradimate acts by absorbing both the UVA and UVB radiation, this provides this ingredient with a broad spectrum and it explains why it is highly used in different products such as lip balms, lipsticks, and moisturizers. Its protective effective action does not cover completely the UVA rays as it only reaches 336 nm. This has been proven even thought meradimate has a theoretical protective coverage range between 200-380 nm. Its function is related to the intrinsic structure of meradimate which is an ortho-disubstituted aminobenzoate. This structure allows easy electron delocalization and shifts in the maximum absorption. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Toxicity:
Classification:
Meradimate belongs to the class of organic compounds known as aromatic monoterpenoids. These are monoterpenoids containing at least one aromatic ring, classified under the direct parent group Aromatic monoterpenoids. This compound is a part of the Organic compounds, falling under the Lipids and lipid-like molecules superclass, and categorized within the Prenol lipids class, specifically within the Monoterpenoids subclass.
Categories:
Meradimate is categorized under the following therapeutic classes: Acids, Carbocyclic, Aminobenzoates, Benzene Derivatives, Benzoates, Sunscreen Agents. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Meradimate include:
- Water Solubility: Insoluble
- Melting Point: 63 ºC
- Boiling Point: 177-179 ºC
Meradimate is a type of Other substances
The pharmaceutical industry encompasses a diverse range of active pharmaceutical ingredients (APIs) that are used in the production of various medications. One category of APIs is known as other substances. This category includes substances that do not fall under the conventional classifications such as antibiotics, analgesics, or antihypertensives.
Other substances in pharmaceutical APIs consist of a broad array of chemical compounds with unique properties and applications. These substances play a crucial role in the formulation and development of specialized medications, catering to specific therapeutic needs. The category encompasses various substances like excipients, solvents, stabilizers, and pH adjusters.
Excipients are inert substances that aid in the manufacturing process and enhance the stability, bioavailability, and patient acceptability of pharmaceutical formulations. Solvents are used to dissolve other ingredients and facilitate their incorporation into the final product. Stabilizers ensure the integrity and shelf life of medications by preventing degradation or chemical changes. pH adjusters help maintain the desired pH level of a formulation, which can influence the drug's efficacy and stability.
Pharmaceutical manufacturers carefully select and incorporate specific other substances into their formulations, adhering to regulatory guidelines and quality standards. These substances undergo rigorous testing and evaluation to ensure their safety, efficacy, and compatibility with the desired pharmaceutical product. By employing other substances in API formulations, pharmaceutical companies can optimize drug delivery, improve patient compliance, and enhance therapeutic outcomes.
In summary, the other substances category of pharmaceutical APIs comprises a diverse range of chemicals, including excipients, solvents, stabilizers, and pH adjusters. These substances contribute to the formulation, stability, and performance of medications, enabling pharmaceutical manufacturers to develop specialized products that meet specific therapeutic requirements.
