Pancrelipase lipase API Manufacturers
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Looking for Pancrelipase lipase API 9001-62-1?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Pancrelipase lipase. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Pancrelipase lipase
- Synonyms:
- Lipase, pancreatic , Pancreatic lipase
- Cas Number:
- 9001-62-1
- DrugBank number:
- DB13147
- Unique Ingredient Identifier:
- 8MYC33932O
General Description:
Pancrelipase lipase, identified by CAS number 9001-62-1, is a notable compound with significant therapeutic applications. Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The pancrelipase lipase is an enzyme secreted by the pancreas that is responsible for the hydrolysis of dietary fat molecules in the human digestive system. The pancrelipase mixture, including pancrelipase lipase, was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and FDA approved on April 12, 2010.
Indications:
This drug is primarily indicated for: Please refer to . Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Pancrelipase lipase undergoes metabolic processing primarily in: Please refer to . This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Pancrelipase lipase are crucial for its therapeutic efficacy: Please refer to . The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Pancrelipase lipase is an important consideration for its dosing schedule: Please refer to . This determines the duration of action and helps in formulating effective dosing regimens.
Protein Binding:
Pancrelipase lipase exhibits a strong affinity for binding with plasma proteins: Please refer to . This property plays a key role in the drug's pharmacokinetics and distribution within the body.
Route of Elimination:
The elimination of Pancrelipase lipase from the body primarily occurs through: Please refer to . Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Pancrelipase lipase is distributed throughout the body with a volume of distribution of: Please refer to . This metric indicates how extensively the drug permeates into body tissues.
Clearance:
The clearance rate of Pancrelipase lipase is a critical factor in determining its safe and effective dosage: Please refer to . It reflects the efficiency with which the drug is removed from the systemic circulation.
Pharmacodynamics:
Pancrelipase lipase exerts its therapeutic effects through: Please refer to . The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Pancrelipase lipase functions by: Pancrelipase lipase catalyzes the hydrolysis of triglycerides to monoglycerides, glycerol, and fatty acids. This activity is performed by the hydrolyzation of the esters of fatty acids. The hydrolysis is started by the action of colipase which helps to anchor lipase to the lipid-water membrane of the micelle producing a surface change on lipase. The hydrophobic active site is exposed for the binding of triglycerides and further interaction with the catalytic triad. In this triad, the function of the three amino acids allows the formation of a deprotonated serine which becomes a nucleophile and act on the ester carbonyl of the fatty acids for the later formation of monoglyceride and fatty acid monomers. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Toxicity:
Classification:
Pancrelipase lipase belongs to the None, classified under the direct parent group Peptides. This compound is a part of the Organic Compounds, falling under the Organic Acids superclass, and categorized within the Carboxylic Acids and Derivatives class, specifically within the Amino Acids, Peptides, and Analogues subclass.
Categories:
Pancrelipase lipase is categorized under the following therapeutic classes: Carboxylic Ester Hydrolases, Enzymes, Enzymes and Coenzymes, Esterases, Gastrointestinal Agents, Hydrolases, Lipase. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Pancrelipase lipase include:
- Water Solubility: Slightly soluble
- Isoelectric Point: 7.4
- Molecular Weight: 48000.0
Pancrelipase lipase is a type of Other substances
The pharmaceutical industry encompasses a diverse range of active pharmaceutical ingredients (APIs) that are used in the production of various medications. One category of APIs is known as other substances. This category includes substances that do not fall under the conventional classifications such as antibiotics, analgesics, or antihypertensives.
Other substances in pharmaceutical APIs consist of a broad array of chemical compounds with unique properties and applications. These substances play a crucial role in the formulation and development of specialized medications, catering to specific therapeutic needs. The category encompasses various substances like excipients, solvents, stabilizers, and pH adjusters.
Excipients are inert substances that aid in the manufacturing process and enhance the stability, bioavailability, and patient acceptability of pharmaceutical formulations. Solvents are used to dissolve other ingredients and facilitate their incorporation into the final product. Stabilizers ensure the integrity and shelf life of medications by preventing degradation or chemical changes. pH adjusters help maintain the desired pH level of a formulation, which can influence the drug's efficacy and stability.
Pharmaceutical manufacturers carefully select and incorporate specific other substances into their formulations, adhering to regulatory guidelines and quality standards. These substances undergo rigorous testing and evaluation to ensure their safety, efficacy, and compatibility with the desired pharmaceutical product. By employing other substances in API formulations, pharmaceutical companies can optimize drug delivery, improve patient compliance, and enhance therapeutic outcomes.
In summary, the other substances category of pharmaceutical APIs comprises a diverse range of chemicals, including excipients, solvents, stabilizers, and pH adjusters. These substances contribute to the formulation, stability, and performance of medications, enabling pharmaceutical manufacturers to develop specialized products that meet specific therapeutic requirements.
