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Technetium Tc-99m mebrofenin
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Looking for Technetium Tc-99m mebrofenin API 1415247-71-0?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Technetium Tc-99m mebrofenin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Technetium Tc-99m mebrofenin
- Synonyms:
- Bis(2-[[2-(3-bromo-2,4,6-trimethylanilino)-2-oxoethyl]-(carboxymethyl)amino]acetate) technetium , Technetium (99mTc) mebrofenin , Technetium Tc 99m diisopropyl-iminodiacetic acid , Technetium Tc 99m DISIDA , Technetium Tc 99m Mebrofenin
- Cas Number:
- 1415247-71-0
- DrugBank number:
- DB09137
- Unique Ingredient Identifier:
- F2NQ468L52
General Description:
Technetium Tc-99m mebrofenin, identified by CAS number 1415247-71-0, is a notable compound with significant therapeutic applications. Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to a technetium-99m ion. Following intravenous injection, single photon emission computer tomography (SPECT) imaging of the liver or gallbladder is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays. This is possible as Technetium-99m decays by isomeric transition to technetium-99 through the release of a gamma ray. Liver and gallbladder imaging is enabled through attachment to mebrofenin as this molecule has high hepatic uptake and fast biliary excretion, resulting in improved hepatic imaging. More specifically, mebrofenin is taken up into hepatocytes through the action of OATP1B1 and OATP1B3 transporters. Currently available within a sterile kit, Tc-99m Mebrofenin is indicated for imaging of the liver and gallbladder.
Indications:
This drug is primarily indicated for: Technetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Absorption:
The absorption characteristics of Technetium Tc-99m mebrofenin are crucial for its therapeutic efficacy: Visualisation in the liver could be detected by 5 minutes and maximum liver uptake occurred at 11 minutes post-injection. Hepatic duct and gallbladder visualization occurred by 10 to 15 minutes and intestinal activity was visualized by 30 to 60 minutes in subjects with normal hepatobiliary function The mean percent injected dose remaining in the blood at 10 minutes was 17%. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Technetium Tc-99m mebrofenin is an important consideration for its dosing schedule: Technetium Tc 99m decays by isomeric transition with a physical half-life of 6.02 hours. This determines the duration of action and helps in formulating effective dosing regimens.
Route of Elimination:
The elimination of Technetium Tc-99m mebrofenin from the body primarily occurs through: The mean percent injected dose excreted in the urine during the first 3 hours was 1%. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Clearance:
The clearance rate of Technetium Tc-99m mebrofenin is a critical factor in determining its safe and effective dosage: Following intravenous administration in normal subjects, Technetium Tc 99m Mebrofenin was rapidly cleared from the circulation. It reflects the efficiency with which the drug is removed from the systemic circulation.
Mechanism of Action:
Technetium Tc-99m mebrofenin functions by: Technetium Tc 99m Mebrofenin has no known pharmacologic activity at the recommended doses. It is used as a diagnostic agent as Technetium-99m decays by isomeric transition to technetium-99 through the release of a detectable gamma ray. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Categories:
Technetium Tc-99m mebrofenin is categorized under the following therapeutic classes: Amines, Amino Acids, Amino Acids, Peptides, and Proteins, Compounds used in a research, industrial, or household setting, Diagnostic Radiopharmaceuticals, Diagnostic Uses of Chemicals, Drugs that are Mainly Renally Excreted, Hepatic and Reticulo Endothelial System, Indicators and Reagents, Laboratory Chemicals, OATP1B1/SLCO1B1 Substrates, OATP1B3 substrates, Organometallic Compounds, Radioactive Diagnostic Agent, Radiopharmaceutical Activity, Radiopharmaceuticals, Technetium (99Mtc) Compounds. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Technetium Tc-99m mebrofenin is a type of Other substances
The pharmaceutical industry encompasses a diverse range of active pharmaceutical ingredients (APIs) that are used in the production of various medications. One category of APIs is known as other substances. This category includes substances that do not fall under the conventional classifications such as antibiotics, analgesics, or antihypertensives.
Other substances in pharmaceutical APIs consist of a broad array of chemical compounds with unique properties and applications. These substances play a crucial role in the formulation and development of specialized medications, catering to specific therapeutic needs. The category encompasses various substances like excipients, solvents, stabilizers, and pH adjusters.
Excipients are inert substances that aid in the manufacturing process and enhance the stability, bioavailability, and patient acceptability of pharmaceutical formulations. Solvents are used to dissolve other ingredients and facilitate their incorporation into the final product. Stabilizers ensure the integrity and shelf life of medications by preventing degradation or chemical changes. pH adjusters help maintain the desired pH level of a formulation, which can influence the drug's efficacy and stability.
Pharmaceutical manufacturers carefully select and incorporate specific other substances into their formulations, adhering to regulatory guidelines and quality standards. These substances undergo rigorous testing and evaluation to ensure their safety, efficacy, and compatibility with the desired pharmaceutical product. By employing other substances in API formulations, pharmaceutical companies can optimize drug delivery, improve patient compliance, and enhance therapeutic outcomes.
In summary, the other substances category of pharmaceutical APIs comprises a diverse range of chemicals, including excipients, solvents, stabilizers, and pH adjusters. These substances contribute to the formulation, stability, and performance of medications, enabling pharmaceutical manufacturers to develop specialized products that meet specific therapeutic requirements.
