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Trioxsalen
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Looking for Trioxsalen API 3902-71-4?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Trioxsalen. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Trioxsalen
- Synonyms:
- trimethylpsoralen , Trioxisaleno , Trioxsalen , trioxysalen , Trioxysalene , Trioxysalenum , trisoralen
- Cas Number:
- 3902-71-4
- DrugBank number:
- DB04571
- Unique Ingredient Identifier:
- Y6UY8OV51T
About Trioxsalen
It's time for some technical information for the ones who understand chemistry: Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. The photoactivated form produces interstrand linkages in DNA resulting in cell apoptosis.
In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.[3] The compound is has been explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.
Ask the supplier for a certificate of analysis to find out more about the quality of Trioxsalen.
Trioxsalen is a type of Psoralens
Psoralens are a class of pharmaceutical active ingredients (APIs) that belong to the subcategory of drugs used in the treatment of various skin conditions. These organic compounds are widely known for their photoreactive properties, making them particularly effective in photochemotherapy, also known as psoralen plus ultraviolet A (PUVA) therapy.
Psoralens function by sensitizing the skin to ultraviolet radiation, specifically UVA wavelengths. When administered orally or topically, psoralens penetrate the skin and interact with DNA, forming covalent bonds upon exposure to UVA light. This process helps modulate cellular functions and suppress abnormal cell growth, making it a valuable treatment option for conditions such as psoriasis, vitiligo, and eczema.
Psoralens come in various forms, including methoxsalen, trioxsalen, and bergapten, among others. These compounds are typically sourced from natural plant extracts, such as figs, limes, and celery seeds. However, synthetic variants are also available.
When using psoralens, it is crucial to ensure proper dosage and exposure to UVA light, as excessive or inadequate levels can lead to adverse effects, including burns and skin damage. Therefore, close medical supervision and adherence to prescribed treatment regimens are vital.
Psoralens have gained recognition as an effective therapy for dermatological conditions, and ongoing research continues to explore their potential applications. As with any pharmaceutical API, it is important to consult healthcare professionals for guidance and follow their recommendations for safe and optimal usage.
Trioxsalen (Psoralens), classified under Others
The others category refers to pharmaceutical APIs that do not fall under specific classifications such as antibiotics, antivirals, analgesics, or cardiovascular drugs. These APIs are diverse in nature and serve various therapeutic purposes, making them a crucial component of pharmaceutical formulations.
Pharmaceutical companies develop APIs in the others category to address specific medical conditions or target novel biological pathways. This category includes APIs used in oncology, neurology, immunology, and other specialized areas of medicine. The APIs in this category are often designed to interact with specific molecular targets or receptors, providing targeted therapeutic effects.
The development of APIs in the others category requires extensive research and testing to ensure their efficacy, safety, and compliance with regulatory standards. Pharmaceutical manufacturers employ advanced techniques such as chemical synthesis, biotechnology, and genetic engineering to produce these APIs.
Due to the broad range of applications and therapeutic uses, APIs in the others category contribute significantly to the advancement of medical treatments. Pharmaceutical companies constantly strive to innovate and discover new APIs within this category to address unmet medical needs and improve patient outcomes.
In conclusion, the others category of pharmaceutical APIs encompasses a diverse range of active ingredients used in drug formulation. These APIs play a crucial role in developing innovative therapies across various therapeutic areas, contributing to advancements in healthcare and patient well-being.
