Simoctocog Alfa API Manufacturers
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Looking for Simoctocog Alfa API 1219013-68-9?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Simoctocog Alfa. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Simoctocog Alfa
- Cas Number:
- 1219013-68-9
- DrugBank number:
- DB09108
- Unique Ingredient Identifier:
- U50VWW6XH6
About Simoctocog Alfa
Here is a short description about Simoctocog alfa. Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the factor VIII in the intrinsic pathway of blood coagulation system.
As patients with haemophilia A are predisposed to episodes of recurrent bleeding simoctocog alfa can be administered for the treatment or prevention of bleeding such as prior to surgical procedures. Simoctocog alfa is a glycoprotein consisting of 1440 amino acids with an approximate molecular mass of 170 kDa, comprising the FVIII domains A1-A2 + A3-C1-C2 whereas the B-domain, present in the full-length plasma-derived FVIII, has been deleted and replaced by a 16 amino acid linker. Simoctocog alfa is a fourth-generation BDD FVIII product made in the human embryonic kidney (HEK) cell line. Full human post-translational modifications via elimination of potentially immunogenic glycosylation patterns found in non-human cell lines led to decreased immunogenicity and longer half-life.
You can find more info about this product by clicking on the DB ID above.
