Tonapofylline API Manufacturers
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Looking for Tonapofylline API 340021-17-2?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Tonapofylline. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Tonapofylline
- Synonyms:
- Cas Number:
- 340021-17-2
- DrugBank number:
- DB12569
- Unique Ingredient Identifier:
- 83VNU4U44T
General Description:
Tonapofylline, identified by CAS number 340021-17-2, is a notable compound with significant therapeutic applications. Tonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and Congestive Heart Failure.
Mechanism of Action:
Tonapofylline functions by: Stimulation of A1 adenosine receptors in the kidney reduces glomerular filtration rate (GFR) via tubuloglomerular feedback and increases sodium reabsorption. Blocking A1 adenosine receptors would therefore maintain GFR and cause natriuresis. Tonapofylline is a xanthine derivative that binds with high affinity to A1 adenosine receptors from several species including human and acts as a competitive antagonist at these receptors. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Tonapofylline belongs to the class of organic compounds known as xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety, classified under the direct parent group Xanthines. This compound is a part of the Organic compounds, falling under the Organoheterocyclic compounds superclass, and categorized within the Imidazopyrimidines class, specifically within the Purines and purine derivatives subclass.
Categories:
Tonapofylline is categorized under the following therapeutic classes: Alkaloids, Heterocyclic Compounds, Fused-Ring, Purines, Purinones, Receptor, Adenosine A1. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
