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Tubocurarine
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Looking for Tubocurarine API 57-95-4?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Tubocurarine. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Tubocurarine
- Synonyms:
- d-tubocurarine , Tubocurarin
- Cas Number:
- 57-95-4
- DrugBank number:
- DB01199
- Unique Ingredient Identifier:
- W9YXS298BM
About Tubocurarine
Why are people looking for Tubocurarine? Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera Chondrodendron and Strychnos. Tubocurarine is a benzylisoquinoline derivative and shares this structural backbone with a number of plant-derived alkaloids, including morphine and papaverine. It was first isolated by Harold King in 1935 and was used clinically to induce neuromuscular blockade during surgeries, particularly those involving the abdomen.
Tubocurarine's clinical use was limited by its relatively long duration of action (30-60 minutes)4 and a number of significant side effects. Safer and more pharmacokinetically favorable non-depolarizing neuromuscular blockers, such as rocuronium, have largely replaced the use of tubocurarine in the clinical setting.
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