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Sodium glycerophosphate
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Looking for Sodium glycerophosphate API 1334-74-3?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Sodium glycerophosphate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Sodium glycerophosphate
- Synonyms:
- Disodium glycerol phosphate , Sodium glycerophosphate anhydrous
- Cas Number:
- 1334-74-3
- DrugBank number:
- DB09561
- Unique Ingredient Identifier:
- G43E72677U
General Description:
Sodium glycerophosphate, identified by CAS number 1334-74-3, is a notable compound with significant therapeutic applications. Sodium glycerophosphate is one of several glycerophosphate salts. It is used clinically to treat or prevent low phosphate levels . Glycerophosphate is hydrolyzed to inorganic phosphate and glycerol in the body . The extent of this reaction is dependent on the activity of serum alkaline phosphatases.
Indications:
This drug is primarily indicated for: Sodium glycerophosphate is indicated for use as a source of phosphate in total parenteral nutrition . It is used in combination with amino acids, dextrose, lipid emulsions, and other electrolytes. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Sodium glycerophosphate undergoes metabolic processing primarily in: Glycerophosphate is hydrolyzed to form inorganic phosphate . The extent of this reaction is dependent on serum alkaline phosphatase activity. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Sodium glycerophosphate are crucial for its therapeutic efficacy: Peak serum phosphate concentration is reached in 4h . The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Sodium glycerophosphate is an important consideration for its dosing schedule: Inorganic phosphate has a half-life of elimination of 2.06h . This determines the duration of action and helps in formulating effective dosing regimens.
Route of Elimination:
The elimination of Sodium glycerophosphate from the body primarily occurs through: Inorganic phosphate produced is eliminated in the urine . There may be a very small amount of glycerophosphate excreted in the urine unchanged. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Pharmacodynamics:
Sodium glycerophosphate exerts its therapeutic effects through: Glycerophosphate acts as a source of inorganic phosphate through hydrolysis . The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Sodium glycerophosphate functions by: Sodium glycerophosphate acts as a donor of inorganic phosphate . See for a description of phosphate's role in the body. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Sodium glycerophosphate belongs to the class of organic compounds known as glycerophosphates. These are compounds containing a glycerol linked to a phosphate group, classified under the direct parent group Glycerophosphates. This compound is a part of the Organic compounds, falling under the Lipids and lipid-like molecules superclass, and categorized within the Glycerophospholipids class, specifically within the Glycerophosphates subclass.
Categories:
Sodium glycerophosphate is categorized under the following therapeutic classes: Alcohols, Blood and Blood Forming Organs, Blood Substitutes and Perfusion Solutions, Carbohydrates, Electrolyte Solutions, I.V. Solution Additives, Lipids, Membrane Lipids, Phosphate salts, Phospholipids, Sugar Alcohols, Sugar Phosphates, Triose Sugar Alcohols. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Sodium glycerophosphate include:
- Water Solubility: Soluble
Sodium glycerophosphate is a type of Additives
Additives in the pharmaceutical API category refer to a group of chemical substances that are incorporated into pharmaceutical products to enhance their stability, functionality, or performance. These additives play a crucial role in ensuring the quality, safety, and efficacy of medications.
One common type of additive used in pharmaceuticals is preservatives. Preservatives are added to prevent microbial growth and maintain the integrity of the product throughout its shelf life. They help to safeguard against contamination and maintain the potency of the active pharmaceutical ingredient (API). Some commonly used preservatives include benzyl alcohol, phenol, and parabens.
Another important group of additives is antioxidants. Antioxidants are added to pharmaceutical formulations to prevent or delay the oxidation of APIs, which can lead to degradation and loss of potency. Examples of antioxidants commonly used in pharmaceuticals include ascorbic acid (vitamin C) and tocopherols (vitamin E).
In addition to preservatives and antioxidants, other additives like flavorings, colorants, and sweeteners may be incorporated into pharmaceutical products to improve their palatability and patient acceptability.
It is crucial to note that the use of additives in pharmaceuticals is strictly regulated by health authorities to ensure their safety and efficacy. Manufacturers must comply with stringent quality control standards and guidelines to guarantee the proper use and appropriate levels of additives in pharmaceutical products.
Overall, additives play a vital role in the pharmaceutical industry by enhancing the stability, functionality, and patient acceptability of medications. Their careful selection and incorporation contribute to the overall quality and effectiveness of pharmaceutical products.
