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Aflibercept
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Established in: 2005
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Looking for Aflibercept API 862111-32-8?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Aflibercept. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Aflibercept
- Synonyms:
- Ziv-Aflibercept , Zaltrap
- Cas Number:
- 862111-32-8
- DrugBank number:
- DB08885
- Unique Ingredient Identifier:
- 15C2VL427D
About Aflibercept
Learn more about Aflibercept. Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa).
It contains approximately 15% glycosylation to give a total molecular weight of 115 kDa. All five putative N-glycosylation sites on each polypeptide chain predicted by the primary sequence can be occupied with carbohydrate and exhibit some degree of chain heterogeneity, including heterogeneity in terminal sialic acid residues, except at the single unsialylated site associated with the Fc domain. Aflibercept, as an ophthalmic agent, is used in the treatment of macular edema following Central Retinal Vein Occlusion (CRVO) and neovascular Age-Related Macular Degeneration (AMD). Ziv-aflibercept, under the brand name Zaltrap, was developed as an injection for treatment of metastatic colorectal cancer. FDA approved in November 18, 2011 and EMA approved in November 2012.
More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.
Aflibercept manufacturers | traders | suppliers
We have 1 companies offering Aflibercept produced in 1 different countries.
Get in contact with the supplier of your choice:
- LGM Pharma from United States, product country of origin World
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