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Calcium glycerophosphate
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Looking for Calcium glycerophosphate API 27214-00-2?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Calcium glycerophosphate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Calcium glycerophosphate
- Synonyms:
- 1,2,3-Propanetriol, mono(dihydrogen phosphate) calcium salt , 1,2,3-Propanetriol, mono(dihydrogen phosphate), calcium salt , Calcium beta-glycerophosphate , calcium β-glycerophosphate , β-glycerophosphoric acid calcium salt
- Cas Number:
- 27214-00-2
- DrugBank number:
- DB11264
- Unique Ingredient Identifier:
- Y56W30YB7O
General Description:
Calcium glycerophosphate, identified by CAS number 27214-00-2, is a notable compound with significant therapeutic applications. Calcium glycerophosphate is a salt of glycerophosphoric acid that forms a white, fine, slightly hygroscopic powder. The commercial product is a mixture of calcium beta-, and D-, and L -alpha-glycerophosphate. By FDA, calcium glycerophosphate is considered a generally recognized as safe (GRAS) food ingredient as a nutrient supplement (source of calcium or phosphorus), or in food products such as gelatins, puddings, and fillings. It is also present in dental or oral hygiene products due to its cariostatic effects. It is suggested that calcium glycerophosphate promotes plaque-pH buffering, elevation of plaque and phosphate levels and direct interaction with dental mineral .
Indications:
This drug is primarily indicated for: Calcium glycerophosphate is found in OTC dental products such as toothpastes for the prevention of dental caries. As OTC products these do not have an official indication. In prescription products it is indicated as a or phosphate donor for replacement or supplementation in patients with insufficient or phosphate. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Pharmacodynamics:
Calcium glycerophosphate exerts its therapeutic effects through: It is thought that calcium glycerophosphate may act through a variety of mechanisms to produce an anti-caries effect . These include increasing acid-resistance of the enamel, increasing enamel mineralization, modifying plaque, acting as a pH-buffer in plaque, and elevating and phosphate levels. When used as an electrolyte replacement, calcium glycerophosphate donates and inorganic phosphate. Calcium glycerophosphate is preferable to calcium phosphate due to its increased solubility. Compared to combination calcium gluconate and potassium phosphate, calcium glycerophosphate produces greater phosphate retention which allows for increased retention and ultimately greater incorporation of the ions into bone structure . The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Calcium glycerophosphate functions by: Calcium glycerophosphate in combination with sodium monofluorophosphate was found to reduce the acid solubility of enamel. This is thought to be due to increased uptake of fluoride in a non-alkali soluble form at the expense of a fraction remaining in the alkali-soluble form of calcium fluoride . It is also thought that calcium glycerophosphate enhances the remineralization effect of sodium monofluorophosphate leading to greater remineralization of enamel but the mechanism behind this is unknown. Calcium glycerophosphate reduces the decrease in plaque pH produced by sucrose solutions . This may be due to the buffering action of donated phosphate which acts as an acceptor to three hydrogen ions to form biphosphate, dihydrogen phosphate, and finally phosphoric acid. As bisphosphate and dihydrogen phosphate are amphoteric, these molecules can act as buffers against both acids and bases. Studies on plaque-modification by calcium glycerophosphate have been inconsistent . Redections in plaque weight and plaque area have been noted in separate studies but neither has been confirmed and no causative link has been established in regards to calcium glycerophosphate's anti-caries effect. Calcium glycerophosphate donates and inorganic phosphate resulting in elevated levels of the ions in plaque . These ions are important components of the mineral structure of teeth. As such, their presence supports maintenance of healthy tooth structure and mineralization. In electrolyte replacement calcium glycerophosphate again acts as a donor of and phosphate. See for pharmacological descriptions of calcium and phosphate. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Calcium glycerophosphate belongs to the class of organic compounds known as glycerophosphates. These are compounds containing a glycerol linked to a phosphate group, classified under the direct parent group Glycerophosphates. This compound is a part of the Organic compounds, falling under the Lipids and lipid-like molecules superclass, and categorized within the Glycerophospholipids class, specifically within the Glycerophosphates subclass.
Categories:
Calcium glycerophosphate is categorized under the following therapeutic classes: Alcohols, Carbohydrates, Glycerophosphates, Lipids, Membrane Lipids, Phospholipids, Sugar Alcohols, Sugar Phosphates, Triose Sugar Alcohols. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Calcium glycerophosphate include:
- Water Solubility: Soluble
- Melting Point: Decomposes at 170
Calcium glycerophosphate is a type of Alkalinizing agents
Alkalinizing agents, a pharmaceutical API category, refers to a group of substances used to increase the pH (alkalinity) of a solution or body fluid. These agents play a crucial role in various medical applications, such as the treatment of acidosis, kidney disorders, and certain drug overdoses.
One commonly used alkalinizing agent is sodium bicarbonate, which is highly effective in raising the pH of blood and urine. It works by neutralizing excess acid and restoring the acid-base balance in the body. Sodium bicarbonate is often administered intravenously in emergency situations to rapidly correct severe acidosis.
Another alkalinizing agent, acetazolamide, is frequently employed in the treatment of glaucoma and certain types of epilepsy. By inhibiting carbonic anhydrase, acetazolamide reduces the production of bicarbonate ions, leading to a systemic decrease in pH. This mechanism is particularly useful in lowering the intraocular pressure associated with glaucoma.
Alkalinizing agents are also utilized in the management of certain drug toxicities. For instance, methotrexate, a chemotherapy medication, can cause severe toxicity if its elimination is hindered. Alkalinizing the urine with agents like sodium bicarbonate enhances methotrexate solubility, preventing the formation of toxic crystals in the kidneys.
In conclusion, alkalinizing agents are indispensable pharmaceutical APIs that help correct acid-base imbalances, treat specific medical conditions, and mitigate drug toxicities. Their diverse applications make them valuable tools in modern medicine.
