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India

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India

Established in: 1984

MOQ: -

Employees: 21,650

Diverse portfolio of 180+APIs

1754+ DMF across global markets

1100+ patents filed, and more than 70 own patents granted

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India

Produced in:

India

Established in: 1989

MOQ: -

Employees: 5000+

6 production facilities approved by USFDA, AGES-Austria, PMDA, WHO

R&D Centers with capabilities of ANDAs, DMFs and NDDS

462+ patents filed for drug substances and polymorphs

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United States

Established in: 1994

MOQ: -

Employees: 50+

26+ years of distribution expertise with regulatory excellence

16 worldwide locations supplying high quality ingredients

All our manufacturer partners are cGMP complaint

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Germany

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Looking for Bendamustine API 16506-27-7?

Description:
Here you will find a list of producers, manufacturers and distributors of Bendamustine. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:
Bendamustine 
Synonyms:
Ribomustine , Levact , Treakisym , Treanda , Bendamustine HCl , Bendamustine Hydrochloride  
Cas Number:
16506-27-7 
DrugBank number:
DB06769 
Unique Ingredient Identifier:
9266D9P3PQ

About Bendamustine

Do you want to know more about Bendamustine? You can find a small explanation about it here. Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death.

It is active against both active and quiescent cells, although the exact mechanism of action is unknown.

Not sure if this is the exact product you're looking for? Contact the supplier by using the send inquiry button.

Bendamustine is a type of Alkylating agents


Alkylating agents are a vital subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a significant role in cancer treatment. These compounds possess the ability to attach alkyl groups to the DNA molecule, effectively disrupting its structure and preventing cell replication. This mechanism of action makes alkylating agents potent chemotherapy drugs for various types of cancers.

Alkylating agents are often classified based on their chemical structure, which includes nitrogen mustards, ethylenimines, nitrosoureas, and alkyl sulfonates, among others. Each subclass exhibits unique chemical properties and therapeutic applications. For instance, nitrogen mustards like cyclophosphamide and mechlorethamine are used to treat lymphomas and leukemia, while nitrosoureas such as carmustine and lomustine are effective against brain tumors.

The alkylating agents' mode of action involves the transfer of alkyl groups to cellular components, primarily DNA. This leads to the formation of DNA adducts, cross-links, and DNA strand breaks, ultimately hindering DNA replication and causing cell death. The indiscriminate nature of alkylating agents can also affect healthy cells, leading to various side effects such as bone marrow suppression and gastrointestinal disturbances.

Despite their potential side effects, alkylating agents remain valuable tools in cancer therapy due to their broad spectrum of activity against different types of tumors. Ongoing research focuses on developing more selective and targeted alkylating agents to improve their therapeutic index and minimize adverse effects. The use of alkylating agents in combination with other chemotherapy drugs or radiation therapy is also being explored to enhance treatment outcomes and reduce drug resistance.

In conclusion, alkylating agents are an essential subclass of pharmaceutical APIs widely employed in cancer treatment. Their ability to disrupt DNA structure and impede cell replication makes them effective against various types of tumors, although careful management of side effects is necessary. Ongoing advancements and research continue to refine their therapeutic potential in the fight against cancer.


Bendamustine (Alkylating agents), classified under Anticancer drugs


Anticancer drugs belong to the pharmaceutical API (Active Pharmaceutical Ingredient) category designed specifically to combat cancer cells. These powerful medications play a crucial role in cancer treatment and are developed to target and destroy cancerous cells, preventing their growth and spread.

Anticancer drugs are classified based on their mode of action and can include various types such as chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, and hormonal therapy drugs. Chemotherapy drugs work by interfering with the cell division process, thereby inhibiting the growth of cancer cells. Targeted therapy drugs, on the other hand, are designed to attack specific molecules or genes involved in cancer growth, minimizing damage to healthy cells. Immunotherapy drugs stimulate the body's immune system to recognize and destroy cancer cells. Hormonal therapy drugs are used in cancers that are hormone-dependent, such as breast or prostate cancer, to block the hormones that fuel cancer cell growth.

These APIs are typically synthesized through complex chemical processes in state-of-the-art manufacturing facilities. Stringent quality control measures ensure the purity, potency, and safety of these drugs. Anticancer APIs undergo rigorous testing and adhere to stringent regulatory guidelines before being approved for clinical use.

Due to their critical role in cancer treatment, anticancer drugs are in high demand worldwide. Researchers and pharmaceutical companies continually strive to develop new and more effective APIs in this category to enhance treatment outcomes and minimize side effects. The ongoing advancements in the field of anticancer drug development offer hope for improved cancer therapies and better patient outcomes.



Bendamustine manufacturers | traders | suppliers

We have 18 companies offering Bendamustine produced in 5 different countries.

Get in contact with the supplier of your choice:

  • Dr. Reddy's from India, product country of origin India
  • Shilpa Medicare Ltd from India, product country of origin India
  • Rochem International, Inc. from United States, product country of origin United States
  • Beijing Huikang Boyuan from China, product country of origin China
  • Heraeus from Germany, product country of origin Germany
  • NAVINTA from United States, product country of origin Unknown
  • Natco Pharma from India, product country of origin India
  • Fujian South Pharma from China, product country of origin China
  • Fuxing Long Rui Pharma from China, product country of origin China
  • Sionc Pharma from India, product country of origin India
  • Lianyungang Runzhong from China, product country of origin China
  • ChemPacific from United States, product country of origin Unknown
  • Sun Pharma from India, product country of origin India
  • Biophore India from India, product country of origin India
  • Hetero Labs from India, product country of origin India
  • Emcure Pharma from India, product country of origin India
  • MSN Labs. from India, product country of origin India
  • Shaoxing Hantai Pharma from China, product country of origin China

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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