- Raw materials
- Amino acids
- L-Tyrosine
Filters
Filter
Custom request?
Type
Production region
Qualifications
Country of origin
L-Tyrosine API Manufacturers & Suppliers
10 verified results
Take control of your API sourcing
Submit a Special Inquiry and have Pharmaoffer activate verified suppliers.
Commercial-scale Suppliers
Producer
Produced in
China|
Employees: 25+
|
Audit Report:
Certifications:
GMP
|
USDMF|
MSDS|
BSE/TSE|
ISO9001All certificates
GMP
USDMF
MSDS
BSE/TSE
ISO9001
CoA
Producer
Produced in
China|
Employees: 300+
|
Audit Report:
Certifications:
GMP
|
USDMF|
MSDS|
BSE/TSE|
ISO9001All certificates
GMP
USDMF
MSDS
BSE/TSE
ISO9001
WC
CoA
Take control of your API sourcing
Submit a Special Inquiry and have Pharmaoffer activate verified suppliers.
Distributor
Produced in
China|
Employees: 50+
|
Audit Report:
Certifications:
USDMF
|
ISO9001|
CoAAll certificates
USDMF
ISO9001
CoA
Producer
Produced in
India|
Employees: 25
|
Audit Report:
Certifications:
GMP
|
MSDS|
ISO9001|
WHO-GMP|
HALALAll certificates
GMP
MSDS
ISO9001
WHO-GMP
HALAL
CoA
Producer
Produced in
Unknown|
Audit Report:
Certifications:
GMP
|
CEP|
CoAAll certificates
GMP
CEP
CoA
Producer
Produced in
Unknown|
Audit Report:
Certifications:
GMP
|
FDA|
CEP|
USDMF|
coaAll certificates
GMP
FDA
CEP
USDMF
coa
Get full market intelligence report
€399,-
All L-Tyrosine data. Full access. Full negotiation power
Producer
Produced in
Unknown|
Audit Report:
Certifications:
USDMF
|
JDMF|
CoAAll certificates
USDMF
JDMF
CoA
Producer
Produced in
China|
Audit Report:
Certifications:
coa
All certificates
coa
Take control of your API sourcing
Producer
Produced in
China|
Audit Report:
Certifications:
coa
All certificates
coa
Producer
Produced in
Japan|
Audit Report:
Certifications:
FDA
|
CEP|
coaAll certificates
FDA
CEP
coa
When insight is your advantage
Full data, full access, full negotiation power
Total market transparency
|
Supplier trade data access
|
Buyer / supplier flow comparison
Trusted by 30,000+ registered pharma professionals:
Reach multinationals, SMEs, compounding pharmacies & more!
Tyrosine | CAS No: 60-18-4 | GMP-certified suppliers
A medication that supports mood‑related applications and is investigated for stress and fatigue‑related conditions, serving nutritional and supplemental uses across key markets.
Therapeutic categories
Amino AcidsAmino Acids, AromaticAmino Acids, CyclicAmino Acids, Peptides, and ProteinsDietary SupplementsProteinogenic Amino Acids
Generic name
Tyrosine
Molecule type
small molecule
CAS number
60-18-4
DrugBank ID
DB00135
Approval status
Approved drug, Investigational drug, Nutraceutical drug
Primary indications
- Tyrosine is claimed to act as an effective antidepressant, however results are mixed
- Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies
Product Snapshot
- Tyrosine is supplied in multiple oral and parenteral formulations, including tablets, solutions, and injectable forms
- It is used in products positioned for mood and stress‐related support and other fatigue‑related applications, although evidence for these uses is mixed
- It is available in the US and Canada with statuses spanning approved, investigational, and nutraceutical categories
Clinical Overview
Tyrosine (CAS 60-18-4) is a non essential aromatic amino acid synthesized endogenously from phenylalanine. It serves as a biochemical precursor for catecholamines, thyroid hormones, and melanin. As a proteinogenic amino acid, it contributes to structural and enzymatic proteins across multiple tissues.
Clinically, tyrosine has been investigated for roles in mood modulation, stress response, narcolepsy, and chronic fatigue, although evidence is inconsistent and some proposed benefits have been refuted. Its relevance in deficiency states is linked to impaired thyroid hormone synthesis and downstream metabolic effects. Tyrosine is also used in nutritional and supplemental contexts, and it appears in several formulations marketed as dietary supplements. No single global reference brand is dominant, as most products are nutritional rather than therapeutic.
Pharmacologically, tyrosine participates in neurotransmitter biosynthesis. As a precursor to dopamine and norepinephrine, it influences catecholaminergic pathways that are associated with mood and cognitive function. These effects are mechanistically attributable to its position in the catecholamine synthesis pathway rather than to direct receptor activity.
Absorption of orally administered tyrosine occurs via active transport in the small intestine, sharing transport systems with other large neutral amino acids. Distribution reflects incorporation into systemic amino acid pools, with competitive uptake across the blood brain barrier. Metabolism primarily involves transamination and degradation via hepatic and extrahepatic pathways, ultimately feeding into energy production or synthesis of downstream hormones and pigments. Tyrosine and its metabolites are eliminated mainly as organic acids and conjugated products.
Safety considerations reflect its physiological role. Excessive supplemental exposure may alter catecholamine balance or interact with conditions affecting thyroid hormone production. Use in individuals with phenylketonuria requires professional oversight because tyrosine metabolism is altered.
For API procurement, suppliers should provide material compliant with pharmacopoeial specifications for amino acids, supported by validated analytical methods, impurity profiling, and controls that ensure consistent stereochemical purity and low bioburden suitable for nutritional or formulation use.
Clinically, tyrosine has been investigated for roles in mood modulation, stress response, narcolepsy, and chronic fatigue, although evidence is inconsistent and some proposed benefits have been refuted. Its relevance in deficiency states is linked to impaired thyroid hormone synthesis and downstream metabolic effects. Tyrosine is also used in nutritional and supplemental contexts, and it appears in several formulations marketed as dietary supplements. No single global reference brand is dominant, as most products are nutritional rather than therapeutic.
Pharmacologically, tyrosine participates in neurotransmitter biosynthesis. As a precursor to dopamine and norepinephrine, it influences catecholaminergic pathways that are associated with mood and cognitive function. These effects are mechanistically attributable to its position in the catecholamine synthesis pathway rather than to direct receptor activity.
Absorption of orally administered tyrosine occurs via active transport in the small intestine, sharing transport systems with other large neutral amino acids. Distribution reflects incorporation into systemic amino acid pools, with competitive uptake across the blood brain barrier. Metabolism primarily involves transamination and degradation via hepatic and extrahepatic pathways, ultimately feeding into energy production or synthesis of downstream hormones and pigments. Tyrosine and its metabolites are eliminated mainly as organic acids and conjugated products.
Safety considerations reflect its physiological role. Excessive supplemental exposure may alter catecholamine balance or interact with conditions affecting thyroid hormone production. Use in individuals with phenylketonuria requires professional oversight because tyrosine metabolism is altered.
For API procurement, suppliers should provide material compliant with pharmacopoeial specifications for amino acids, supported by validated analytical methods, impurity profiling, and controls that ensure consistent stereochemical purity and low bioburden suitable for nutritional or formulation use.
Identification & chemistry
| Generic name | Tyrosine |
|---|---|
| Molecule type | Small molecule |
| CAS | 60-18-4 |
| UNII | 42HK56048U |
| DrugBank ID | DB00135 |
Pharmacology
| Summary | Tyrosine is a nonessential amino acid derived from phenylalanine and serves as a metabolic precursor for catecholamine neurotransmitters, including norepinephrine and dopamine. Its pharmacologic effects relate to its role in protein synthesis and in pathways involving enzymes such as tyrosine hydroxylase and tyrosine aminotransferase. Proposed neuropsychiatric or stress-related uses are based on its biochemical functions, though supporting evidence remains inconsistent. |
|---|---|
| Mechanism of action | Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the phenylalanine required goes into the production of tyrosine; if the diet is rich in tyrosine itself, the requirements for phenylalanine are reduced by about 50%. The mechanism of L-tyrosine's antidepressant activity can be accounted for by the precursor role of L-tyrosine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects. |
| Pharmacodynamics | Tyrosine is a nonessential amino acid synthesized in the body from phenylalanine. Tyrosine is critical for the production of the body's proteins, enzymes and muscle tissue. Tyrosine is a precursor to the neurotransmitters norepinephrine and dopamine. It can act as a mood elevator and an anti-depressant. It may improve memory and increase mental alertness. Tyrosine aids in the production of melanin and plays a critical role in the production of thyroxin (thyroid hormones). Tyrosine deficiencies are manifested by hypothyroidism, low blood pressure and low body temperature. Supplemental tyrosine has been used to reduce stress and combat narcolepsy and chronic fatigue. |
Targets
| Target | Organism | Actions |
|---|---|---|
| Tyrosine 3-monooxygenase | Humans | binder |
| Tyrosine--tRNA ligase, mitochondrial | Humans | |
| Tyrosine--tRNA ligase, cytoplasmic | Humans |
ADME / PK
| Absorption | L-tyrosine is absorbed from the small intestine by a sodium-dependent active transport process. |
|---|---|
| Metabolism | In the liver, L-tyrosine is involved in a number of biochemical reactions, including protein synthesis and oxidative catabolic reactions. L-tyrosine that is not metabolized in the liver is distributed via the systemic circulation to the various tissues of the body. |
Formulation & handling
- Suitable for both oral solid forms and aqueous parenteral solutions due to high water solubility and small‑molecule characteristics.
- Stable as a solid, but parenteral formulations may require pH control to maintain solubility and prevent precipitation in concentrated solutions.
- Widely compatible with emulsion or solution systems for intravenous nutrition or supplementation, with minimal special handling needs beyond standard amino‑acid solution practices.
Regulatory status
| Lifecycle | With key patent protections in Canada and the US either expired or approaching expiry, the API is entering a mature stage of its lifecycle. Market activity in both regions reflects a shift toward broader generic participation. |
|---|
| Markets | Canada, US |
|---|
Supply Chain
| Supply chain summary | Tyrosine is supplied by a small group of established packagers, indicating a concentrated but stable manufacturing base for this amino‑acid ingredient. The branded parenteral nutrition products containing tyrosine are marketed in the US and Canada, reflecting a primarily North American commercial presence. As a basic nutrient component without active patent protection, it is already available for broad generic use. |
|---|
Safety
| Toxicity | L-Tyrosine has very low toxicity. There have been very few reports of toxicity. LD<sub>50</sub> (oral, rat) > 5110 mg/kg. |
|---|
High Level Warnings:
- Exhibits very low acute toxicity
- Oral LD50 in rats exceeds 5110 mg/kg, indicating wide safety margins under normal handling conditions
- Dust generation should be minimized, as fine particulate material may cause mild transient irritation to respiratory or ocular tissues
L-Tyrosine is a type of Amino acids
Amino acids are an essential category of pharmaceutical active pharmaceutical ingredients (APIs) widely used in the pharmaceutical industry. These organic compounds are the building blocks of proteins and play a crucial role in various biological processes. With their increasing popularity and therapeutic potential, amino acids have become a focus of research and development in drug discovery.
Amino acids can be classified into two main categories: essential and non-essential. Essential amino acids cannot be synthesized by the body and must be obtained from dietary sources or through pharmaceutical supplementation. Non-essential amino acids, on the other hand, can be synthesized by the body itself.
Pharmaceutical-grade amino acids are produced through a variety of methods, including extraction from natural sources, fermentation, and chemical synthesis. They undergo rigorous quality control procedures to ensure purity, efficacy, and safety. The most common amino acids used as APIs include lysine, valine, leucine, isoleucine, phenylalanine, and methionine, among others.
Amino acids have diverse applications in the pharmaceutical industry. They are widely used as ingredients in parenteral nutrition formulations, where they provide essential nutrients to patients who cannot consume food orally. Additionally, amino acids are utilized in the development of protein-based drugs, such as monoclonal antibodies and recombinant proteins. These pharmaceutical proteins often require specific amino acid sequences to achieve desired therapeutic effects.
In conclusion, amino acids are a vital category of pharmaceutical APIs, playing a significant role in protein synthesis, nutrition, and the development of protein-based drugs. With their extensive applications and growing demand, amino acids continue to contribute to advancements in the pharmaceutical industry.
L-Tyrosine API manufacturers & distributors
Compare qualified L-Tyrosine API suppliers worldwide. We currently have 10 companies offering L-Tyrosine API, with manufacturing taking place in 4 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Ajinomoto | Producer | Japan | Unknown | CoA, JDMF, USDMF | 24 products |
| Amino Chemicals | Producer | Malta | Unknown | CEP, CoA, GMP | 20 products |
| Amino GmbH | Producer | Germany | Unknown | CEP, CoA, FDA, GMP, USDMF | 17 products |
| Innovative Healthcare | Producer | India | India | CoA, GMP, HALAL, ISO9001, MSDS, WHO-GMP | 10 products |
| Sekisui Medical | Producer | Japan | Japan | CEP, CoA, FDA | 11 products |
| Senova Technology Co., Lt... | Producer | China | China | BSE/TSE, CoA, GMP, ISO9001, MSDS, USDMF | 157 products |
| Shandong Yangcheng | Producer | China | China | CoA | 4 products |
| Sinoway industrial Co.,Lt... | Distributor | China | China | CoA, ISO9001, USDMF | 762 products |
| Wuhan Amino Acid Bio-Chem... | Producer | China | China | CoA | 32 products |
| Wuxi Jinghai Amino Acid C... | Producer | China | China | BSE/TSE, CoA, GMP, ISO9001, MSDS, USDMF, WC | 15 products |
When sending a request, specify which L-Tyrosine API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality L-Tyrosine API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
Frequently asked questions about L-Tyrosine API
Sourcing
What matters most when sourcing GMP-grade L-Tyrosine?
The key factors are compliance with U.S. and Canadian GMP and verification that the supplier follows established quality controls for amino‑acid ingredients. Because production is concentrated among a small group of established packagers, confirming their regulatory track record and audit history is essential. It is also important to ensure the material meets specifications suitable for parenteral nutrition use when applicable.
Which documents are typically required when sourcing L-Tyrosine API?
Request the core API documentation set: CoA (9 companies), USDMF (5 companies), GMP (4 companies), CEP (3 companies), ISO9001 (3 companies). Confirm versions and validity dates match the destination market to avoid delays in qualification.
Which manufacturers are known to produce L-Tyrosine API?
Known or reported manufacturers for L-Tyrosine: Senova Technology Co., Ltd., Sinoway industrial Co.,Ltd, Wuxi Jinghai Amino Acid Co., Ltd. Evaluate their GMP history, scale, and regional coverage before requesting dossiers or allocating demand.
How can I request quotes for L-Tyrosine API from GMP suppliers?
Submit quote requests through the supplier listings with your specs and required documents (specifications, target volume, delivery timeline, and destination). Providing consistent details upfront speeds comparable offers and clarifies technical feasibility.
Is a GMP audit report available for L-Tyrosine manufacturers?
Audit reports may be requested for L-Tyrosine: 3 GMP audit reports available. Confirm the scope and recency of any audit before relying on it for qualification decisions.
How many suppliers offer L-Tyrosine API on Pharmaoffer?
Reported supplier count for L-Tyrosine: 9 verified suppliers. Filter listings by certifications, regions, and delivery options to match your qualification plan.
Which countries are known to manufacture L-Tyrosine API?
Production countries reported for L-Tyrosine: China (5 producers), Japan (1 producer). Knowing the manufacturing geography helps anticipate logistics lead times and import compliance needs.
Which certifications do suppliers of L-Tyrosine usually hold?
Common certifications for L-Tyrosine suppliers: CoA (9 companies), USDMF (5 companies), GMP (4 companies), CEP (3 companies), ISO9001 (3 companies). Always verify issuing authorities and expiry dates when reviewing audit packages.
Technical
What is L-Tyrosine (CAS 60-18-4) used for?
L-Tyrosine is used in nutritional formulations as a non‑essential amino acid that supports general protein synthesis and serves as a precursor to catecholamines, thyroid hormones, and melanin. It is included in supplements and studied for roles in mood and stress modulation based on its position in dopamine and norepinephrine biosynthesis. It may also be applied in contexts where altered L-Tyrosine or phenylalanine metabolism affects thyroid hormone production.
Which therapeutic class does L-Tyrosine fall into?
L-Tyrosine belongs to the following therapeutic categories: Amino Acids, Amino Acids, Aromatic, Amino Acids, Cyclic, Amino Acids, Peptides, and Proteins, Dietary Supplements. This positioning helps teams compare alternative APIs, anticipate pharmacology expectations, and align early research priorities.
What conditions is L-Tyrosine mainly prescribed for?
The primary indications for L-Tyrosine: L-Tyrosine is claimed to act as an effective antidepressant, however results are mixed, L-Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies. These use cases frame the target patient populations and help prioritize formulation and safety evaluations.
How does L-Tyrosine work?
L-Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the phenylalanine required goes into the production of L-Tyrosine; if the diet is rich in L-Tyrosine itself, the requirements for phenylalanine are reduced by about 50%. The mechanism of L-Tyrosine's antidepressant activity can be accounted for by the precursor role of L-Tyrosine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.
What should someone know about the safety or toxicity profile of L-Tyrosine?
L-Tyrosine shows very low acute toxicity, with an oral LD50 in rats greater than 5110 mg/kg, indicating a broad safety margin under normal use. Dust should be controlled during handling, as fine particles may cause mild, transient respiratory or eye irritation. Excessive supplemental intake may influence catecholamine or thyroid hormone balance, and individuals with phenylketonuria require supervised use due to altered metabolism.
What are important formulation and handling considerations for L-Tyrosine as an API?
Important considerations include its high water solubility, which supports use in oral solids and aqueous parenteral solutions. Solid forms are generally stable, while parenteral preparations may need pH adjustment to maintain solubility and prevent precipitation at higher concentrations. It is compatible with standard amino‑acid solution and emulsion systems, and handling aligns with routine practices for sterile aqueous formulations.
Is L-Tyrosine a small molecule?
L-Tyrosine is classified as a small molecule. That classification shapes process design, impurity profiling, and analytical control strategies.
Are there special stability concerns for oral L-Tyrosine?
Oral L-Tyrosine is generally stable, with no special stability concerns beyond standard handling for solid amino‑acid formulations. It remains stable in solid form, and its high water solubility supports reliable dissolution during administration. Stability considerations noted for concentrated parenteral solutions, such as pH control, do not apply to typical oral products.
Regulatory
Where is L-Tyrosine approved or in use globally?
L-Tyrosine is reported as approved in the following major regions: Canada, US. Understanding geographic coverage informs regulatory filings, supply planning, and risk assessments before escalating procurement.
What’s the regulatory and patent landscape for L-Tyrosine right now?
In Canada and the United States, L-Tyrosine is regulated within existing national frameworks for ingredients used in health‑related products. It must comply with each country’s applicable quality and safety requirements. The provided context does not note any active patent protections for L-Tyrosine.
Pharmaoffer
How does Pharmaoffer’s Smart Sourcing Service help with L-Tyrosine procurement?
Pharmaoffer's Smart Sourcing Service coordinates compliant suppliers, documentation, and competitive quotes for L-Tyrosine. It centralizes outreach, follow-ups, and document validation to shorten procurement timelines.
Is L-Tyrosine included in the PRO Data Insights coverage?
PRO Data Insights coverage for L-Tyrosine: 2825 verified transactions across 598 suppliers and 447 buyers worldwide. Use the dataset to benchmark suppliers and monitor regulatory activity where available.
Where can I access the API market report for L-Tyrosine?
Market report availability for L-Tyrosine: Report Available. The report highlights demand trends, pricing drivers, and supplier landscape insights for procurement planning.
