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Aminophenazone | CAS No: 58-15-1 | GMP-certified suppliers
A medication that provides analgesic, anti-inflammatory, and antipyretic effects, historically used for rheumatism and neuritis, and currently utilized in diagnostic measurement of total body water.
Therapeutic categories
Primary indications
- Formerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds
- Currently used to measure total body water
Product Snapshot
- Aminophenazone is available in oral and rectal formulations including tablets, solutions, and suppositories
- It has been primarily used for antipyretic and analgesic applications in conditions such as rheumatism and neuritis, and is currently utilized for measuring total body water
- The compound has an approval history but has been withdrawn from certain markets
Clinical Overview
Pharmacodynamically, aminophenazone demonstrates non-steroidal anti-inflammatory action, providing symptomatic relief of pain and fever. Mechanistically, it is metabolized primarily through hepatic cytochrome P450 enzymes, including CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, and CYP3A4 isoforms, acting as both substrate and inhibitor to several of these pathways. This extensive involvement with multiple CYP450 enzymes impacts potential drug-drug interactions and metabolic clearance.
Pharmacokinetic data reveal that aminophenazone undergoes slow metabolism in neonates, with increased metabolic conversion evidenced by higher exhaled 13-CO2 in older infants when administered as 13C-labeled aminophenazone. This property has been exploited in biomedical research and diagnostics, notably in breath tests assessing cytochrome P450 metabolic activity and in measuring total body water content.
Safety considerations center on its association with agranulocytosis, a potentially fatal hematologic adverse effect, alongside contraindications related to nephrotoxicity, hyperkalemia, and hypertension. These factors have led to restricted therapeutic use and regulatory withdrawal in several countries.
Aminophenazone has limited contemporary clinical application but remains of interest in specialized diagnostic contexts. For API sourcing, strict adherence to quality standards including impurity profiling, control of residual solvents, and confirmation of isotopic labeling when applicable, is essential to ensure batch consistency and compliance with pharmacopeial monographs or regulatory expectations. Suppliers must demonstrate validated manufacturing processes to mitigate the presence of toxic impurities associated with pyrazolone derivatives.
Identification & chemistry
| Generic name | Aminophenazone |
|---|---|
| Molecule type | Small molecule |
| CAS | 58-15-1 |
| UNII | 01704YP3MO |
| DrugBank ID | DB01424 |
Pharmacology
| Summary | Aminophenazone is an analgesic, anti-inflammatory, and antipyretic agent that exerts its effects through metabolic pathways influencing prostaglandin synthesis. Its pharmacodynamics involve modulation of inflammatory and pain responses. The compound is primarily utilized as a metabolic tracer to assess total body water due to its distinctive biotransformation profile. |
|---|---|
| Mechanism of action | Aminophenazone is metabolized very slowly by normal newborn babies. In older infants, a higher amount of exhaled 13-CO2 is observed. |
| Pharmacodynamics | Aminophenazone exhibits analgesic, anti-inflammatory, and antipyretic properties. |
Formulation & handling
- Aminophenazone is a small molecule suitable for oral and rectal administration but not for injectable formulations.
- As a phenylpyrazole derivative, it exhibits moderate water solubility and low to moderate lipophilicity impacting formulation strategies.
- Stability data suggest standard handling but formulation should consider potential sensitivity to degradation in aqueous solutions over time.
Regulatory status
Safety
| Toxicity | Can cause life-threatening agranulocytosis. |
|---|
- Handling requires strict adherence to protective equipment protocols to prevent exposure due to risk of severe hematological toxicity
- Avoid inhalation and dermal contact
- Agranulocytosis risk necessitates minimized worker exposure
Aminophenazone is a type of Analgesics
Analgesics are a category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that are commonly used to relieve pain. They are designed to alleviate discomfort by targeting the body's pain receptors or by reducing inflammation. Analgesics are widely utilized in the medical field to manage various types of pain, ranging from mild to severe.
One of the primary classes of analgesics is nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by inhibiting the production of prostaglandins, substances that contribute to pain and inflammation. This class includes well-known drugs like ibuprofen and naproxen. Another class of analgesics is opioids, which are derived from opium or synthetic compounds that mimic the effects of opium. Opioids act on the central nervous system to reduce pain perception and provide potent pain relief. Examples of opioids include morphine, codeine, and oxycodone.
Analgesics are available in various forms, such as tablets, capsules, creams, and injections, allowing for different routes of administration based on the patient's needs. They are commonly used to manage pain associated with conditions like arthritis, headaches, dental procedures, and post-operative recovery.
It is important to note that analgesics should be used under medical supervision, as improper use or overuse can lead to adverse effects, including gastrointestinal complications, addiction, and respiratory depression in the case of opioids. Therefore, it is crucial for healthcare professionals to assess each patient's individual needs and prescribe the appropriate analgesic and dosage.
In summary, analgesics are a vital category of pharmaceutical APIs used to alleviate pain by targeting pain receptors or reducing inflammation. With various classes and forms available, they provide valuable options for pain management when used responsibly and under medical guidance.
Aminophenazone API manufacturers & distributors
Compare qualified Aminophenazone API suppliers worldwide. We currently have 5 companies offering Aminophenazone API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Aurora Industry Co., Ltd | Distributor | China | China | BSE/TSE, CEP, CoA, FDA, GMP, ISO9001, MSDS, USDMF, WC | 250 products |
| Chr. Olesen Group | Distributor | Denmark | China | CEP, CoA, USDMF | 252 products |
| Shandong Xinhua | Producer | China | China | CoA, WC | 21 products |
| Xellia (Taizhou) | Producer | China | China | CoA, WC | 8 products |
| Zhejiang Haisen Pharma | Producer | China | China | CoA, WC | 7 products |
When sending a request, specify which Aminophenazone API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Aminophenazone API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
