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Looking for Zileuton API 111406-87-2?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Zileuton. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Zileuton
- Synonyms:
- Leutrol , Zileuton , Zileuton , Zileutonum , Zyflo
- Cas Number:
- 111406-87-2
- DrugBank number:
- DB00744
- Unique Ingredient Identifier:
- V1L22WVE2S
About Zileuton
Want to know more about Zileuton? Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation.
Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. The immediate release tablet of Zileuton has been withdrawn from the US market.
More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.
Zileuton is a type of Anti-asthma
Anti-asthma pharmaceutical APIs are a category of active pharmaceutical ingredients (APIs) specifically developed to combat asthma, a chronic respiratory condition characterized by inflammation and narrowing of the airways. These APIs play a crucial role in the formulation of effective medications used to manage and treat asthma symptoms.
The primary objective of anti-asthma pharmaceutical APIs is to alleviate airway inflammation and bronchospasms, which are the major factors contributing to asthma attacks. These APIs target specific cellular receptors involved in the inflammatory response, such as leukotriene receptors and beta-2 adrenergic receptors.
Corticosteroids are a common class of anti-asthma APIs used to suppress inflammation in the airways. They work by inhibiting the production of inflammatory molecules, thereby reducing swelling and mucus production. Beta-2 agonists are another essential group of APIs that act on the beta-2 adrenergic receptors in the airway smooth muscles, leading to relaxation and opening of the airways.
Anti-asthma APIs are carefully synthesized and purified to meet stringent quality standards, ensuring their safety and efficacy. Extensive research and development efforts go into optimizing the pharmacological properties of these APIs, including their bioavailability, stability, and compatibility with different formulations.
Pharmaceutical companies utilize anti-asthma APIs to develop various dosage forms, including inhalers, tablets, and injections. These APIs are often combined with other excipients and technologies to enhance drug delivery and improve patient compliance.
In conclusion, anti-asthma pharmaceutical APIs are critical components in the development of medications that effectively manage asthma symptoms. They target key mechanisms underlying asthma pathophysiology, providing relief from airway inflammation and bronchospasms. These APIs enable the formulation of safe and efficient anti-asthma drugs, empowering individuals with asthma to lead healthier lives.
Zileuton manufacturers | traders | suppliers
We have 5 companies offering Zileuton produced in 3 different countries.
Get in contact with the supplier of your choice:
- Emcure Pharma from India, product country of origin India
- MSN Labs. from India, product country of origin India
- Farmak from Czech Republic, product country of origin Czech Republic
- Biophore India from India, product country of origin India
- Erregierre from Italy, product country of origin Italy
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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