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Chlortetracycline | CAS No: 57-62-5 | GMP-certified suppliers
A medication that provides broad-spectrum antibacterial and antiparasitic activity for use in medicated animal feeds supporting veterinary health applications.
Therapeutic categories
Primary indications
- Used in the manufacuring of medicated animal feeds
Product Snapshot
- Chlortetracycline is available in multiple formulations including topical creams, ointments, ophthalmic solutions, and oral capsules
- It is primarily used in the manufacture of medicated animal feeds and for veterinary applications
- The product is approved for veterinary use in the Canadian market and has investigational status
Clinical Overview
Clinically, chlortetracycline is primarily utilized in the manufacturing of medicated animal feeds, as indicated by the FDA. It holds approvals within veterinary medicine and is also recognized for investigational and approved uses related to antibacterial activity.
Pharmacodynamically, chlortetracycline functions as a bacteriostatic agent. Its antimicrobial effect arises from inhibition of bacterial protein synthesis. Mechanistically, it binds competitively to the A site of the bacterial 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA. This prevents elongation of the peptide chain, thereby suppressing bacterial growth and reproduction.
Key absorption, distribution, metabolism, and excretion (ADME) characteristics include moderate oral bioavailability, extensive tissue distribution, and renal elimination. Like other tetracyclines, it may undergo some degree of hepatic metabolism, though detailed metabolic pathways require further elucidation.
Safety considerations for chlortetracycline reflect the general profile of tetracycline antibiotics. Potential adverse effects include gastrointestinal disturbances, photosensitivity reactions, and, rarely, effects on bone and tooth development in juveniles. Its use is contraindicated in pregnant animals and those with impaired hepatic or renal function due to possible toxicity. Resistance development among target bacteria is a documented concern and influences clinical utility.
Notable product formulations predominantly address animal health applications, including topical, oral, and feed-additive forms.
For API sourcing, quality parameters should be consistent with pharmacopoeial standards, ensuring purity, controlled polymorphic form, and absence of residual solvents or microbial contamination. Reliable supply chains and compliance with Good Manufacturing Practice (GMP) are critical to support veterinary pharmaceutical production and regulatory submission requirements.
Identification & chemistry
| Generic name | Chlortetracycline |
|---|---|
| Molecule type | Small molecule |
| CAS | 57-62-5 |
| UNII | WCK1KIQ23Q |
| DrugBank ID | DB09093 |
Pharmacology
| Summary | Chlortetracycline is a bacteriostatic antibiotic that inhibits bacterial growth by binding to the 30S ribosomal subunit, specifically targeting 16S rRNA and associated ribosomal proteins. This binding blocks the attachment of aminoacyl-tRNA to the A site, preventing protein synthesis. Its primary therapeutic use is in the production of medicated animal feeds to control bacterial proliferation. |
|---|---|
| Mechanism of action | Chlortetracycline, like other tetracyclines, competes for the A site of the bacterial ribosome . This binding competes with tRNA carrying amino acids preventing the addition of more amino acids to the peptide chain. This inhibition of protein synthesis ultimately inhibits growth and reproduction of the bacterial cell as necessary proteins cannot be synthesized. |
| Pharmacodynamics | Tetracycline antibiotics are bacteriostatic agents which act to inhibit bacterial growth and reproduction . |
Targets
| Target | Organism | Actions |
|---|---|---|
| 16S ribosomal RNA | Enteric bacteria and other eubacteria | inhibitor |
| 30S ribosomal protein S3 | Escherichia coli (strain K12) | inhibitor |
| 30S ribosomal protein S8 | Escherichia coli (strain K12) | inhibitor |
ADME / PK
| Absorption | Chortetracycline reaches peak plasma concentation in about 3 hours . Its oral bioavailability is 25-30%. |
|---|---|
| Half-life | The half-life of Chlortetracycline is 5.6 hours . |
| Protein binding | Chlortetracline is 50-55% bound to plasma proteins . |
| Metabolism | Chlortetracycline is not known to undergo significant metabolism . |
| Route of elimination | Chlortetracycline is mainly eliminated in feces . Renal function does not appear to affect the rate of elimination. |
| Volume of distribution | Chlortetracycline has a volume of distribution of 100 liters . |
Formulation & handling
- Chlortetracycline is a small molecule tetracycline antibiotic primarily used in topical, ophthalmic, and vaginal formulations rather than injectable or oral systemic forms.
- The compound has low water solubility and a hydrophilic nature (LogP -2.9), requiring appropriate formulation strategies to enhance bioavailability in topical applications.
- Formulations should consider light and moisture sensitivity typical of tetracyclines to maintain stability and potency during storage and handling.
Regulatory status
| Lifecycle | The API’s primary patent protection in Canada is set to expire within the next 12 months, allowing for the introduction of generic alternatives. The market is currently transitioning from exclusivity to increased competition. |
|---|
| Markets | Canada |
|---|
Supply Chain
| Supply chain summary | The manufacturing landscape for chlortetracycline includes multiple originator companies producing branded products such as Aureomycin, which hold a notable presence in the Canadian market. These branded formulations are primarily distributed within regional markets like Ontario, with limited global reach indicated. Patent expirations for chlortetracycline have led to established generic competition, suggesting a mature supply chain with both branded and generic suppliers. |
|---|
Safety
| Toxicity | The acute oral LD50 in mice is 2314mg/kg [MSDS].The most common adverse effects of tertacylines are gastrointestinal disturbances, and staining of teeth and bone. Some occurences of dental hypoplasia and bone deformity have been noted . In pregnant women tetracyclines may produce hepatotoxicity. |
|---|
- Acute oral toxicity in mice: LD50 of 2314 mg/kg
- Potential for gastrointestinal irritation and staining of teeth and bone upon exposure
- Reported cases of dental hypoplasia and bone deformities
Chlortetracycline is a type of Antibacterials
Antibacterials, a category of pharmaceutical active pharmaceutical ingredients (APIs), play a crucial role in combating bacterial infections. These APIs are chemical compounds that target and inhibit the growth or kill bacteria, helping to eliminate harmful bacterial pathogens from the body.
Antibacterials are essential for the treatment of various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and more. They are commonly prescribed by healthcare professionals to combat both mild and severe bacterial infections.
Within the category of antibacterials, there are different classes and subclasses of APIs, each with distinct mechanisms of action and target bacteria. Some commonly used antibacterials include penicillins, cephalosporins, tetracyclines, macrolides, and fluoroquinolones. These APIs work by interfering with various aspects of bacterial cellular processes, such as cell wall synthesis, protein synthesis, DNA replication, or enzyme activity.
The development and production of antibacterial APIs require stringent quality control measures to ensure their safety, efficacy, and purity. Pharmaceutical manufacturers must adhere to Good Manufacturing Practices (GMP) and follow rigorous testing protocols to guarantee the quality and consistency of these APIs.
As bacterial resistance to antibiotics continues to be a significant concern, ongoing research and development efforts aim to discover and develop new antibacterial APIs. The evolution of antibacterials plays a crucial role in combating emerging bacterial strains and ensuring effective treatment options for infectious diseases.
In summary, antibacterials are a vital category of pharmaceutical APIs used to treat bacterial infections. They are designed to inhibit or kill bacteria, and their development requires strict adherence to quality control standards. By continually advancing research in this field, scientists and pharmaceutical companies can contribute to the ongoing battle against bacterial infections.
Chlortetracycline API manufacturers & distributors
Compare qualified Chlortetracycline API suppliers worldwide. We currently have 4 companies offering Chlortetracycline API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Aurora Industry Co., Ltd | Distributor | China | China | BSE/TSE, CEP, CoA, FDA, GMP, ISO9001, MSDS, USDMF, WC | 250 products |
| Fujian Fukang Pharma | Producer | China | China | CoA, USDMF, WC | 4 products |
| Shaoxing Hantai Pharma | Distributor | China | China | CoA | 162 products |
| Sinoway industrial Co.,Lt... | Distributor | China | China | CEP, CoA, GMP, ISO9001, MSDS, USDMF | 757 products |
When sending a request, specify which Chlortetracycline API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Chlortetracycline API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
