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Looking for Barbexaclone API 4388-82-3?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Barbexaclone. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Barbexaclone
- Synonyms:
- Barbexaclon , Barbexaclone , Barbexaclonum , Barbexaclona
- Cas Number:
- 4388-82-3
- DrugBank number:
- DB09001
- Unique Ingredient Identifier:
- 291GX1YB65
About Barbexaclone
So, what does it do? Barbexaclone, a salt compound of propylhexedrine and phenobarbital, is a potent antiepileptic. By weight, barbexaclone is 40% propylhexedrine and 60% phenobarbital. While barbexaclone has sedative properties, propylhexedrine has psychostimulant properties intended to offset these sedative effects. Pharmacokinetic studies have demonstrated that the pharmacokinetics of phenobarbital given as barbexaclone are not affected by propylhexedrine.
Several reports from Spanish and Italian literature suggest that barbexaclone is at least as effective as phenobarbital in adults and children, while being better tolerated and having less sedative properties. These reports were conducted in a small series of patients in the 1970s and 1980s, and have yet to be confirmed by larger controlled trials. Despite the lack of controlled trials, barbexaclone was used widely in Turkey until it was discontinued in 2009. Barbexaclone exists in 25mg and 100mg tablets.00mg of barbexaclone is equivalent to 60mg of phenobarbital. With this difference in potency in mind, other pharmacokinetic considerations such as dose titration, daily dosing, and optimal plasma concentration can be considered the same as for the equivalent amount of phenobarbital.
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Barbexaclone is a type of Antiepileptics
Antiepileptics, also known as antiseizure or anticonvulsant drugs, belong to the pharmaceutical category of active pharmaceutical ingredients (APIs) used for the treatment of epilepsy and other seizure disorders. These medications work by modulating the activity of neurotransmitters and ion channels in the brain to prevent or reduce the occurrence of seizures.
Antiepileptic APIs are classified into various chemical classes, including hydantoins, barbiturates, benzodiazepines, succinimides, and others. Each class of antiepileptics exerts its therapeutic effects through distinct mechanisms, targeting different components of the brain's neural network involved in seizure generation and propagation.
These APIs are typically formulated into oral tablets, capsules, or liquids for easy administration. Some antiepileptic drugs are also available in injectable forms for emergency situations. The dosage and treatment duration vary based on the patient's age, seizure type, and medical history.
The development of antiepileptic APIs requires rigorous research, including preclinical and clinical trials, to establish safety, efficacy, and optimal dosing regimens. Pharmaceutical companies follow strict quality control standards to ensure the purity, stability, and consistent quality of these APIs.
While antiepileptics are primarily used for epilepsy management, they are also prescribed for other neurological conditions such as bipolar disorder, neuropathic pain, and migraine prophylaxis. However, it is important to note that these medications may have potential side effects, including drowsiness, dizziness, cognitive impairment, and mood changes, which should be carefully monitored by healthcare professionals.
In conclusion, antiepileptics represent a crucial category of pharmaceutical APIs utilized in the treatment of epilepsy and other seizure disorders. These drugs play a vital role in managing and improving the quality of life for individuals affected by these conditions, helping to reduce the frequency and severity of seizures.
Barbexaclone manufacturers | traders | suppliers
We have 1 companies offering Barbexaclone produced in 1 different countries.
Get in contact with the supplier of your choice:
- S.A.L.A.R.S. from Italy, product country of origin Italy
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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