Pirfenidone API Manufacturers & Suppliers

Looking for Pirfenidone API 53179-13-8?

Description:

Here you will find a list of producers, manufacturers and distributors of Pirfenidone. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Pirfenidone 

Cas Number:

53179-13-8 

DrugBank number:

DB04951 

Unique Ingredient Identifier:

D7NLD2JX7U

Pirfenidone is a type of Antifibrotic agents

Antifibrotic agents belong to the pharmaceutical API category that focuses on treating fibrosis, a condition characterized by the excessive accumulation of fibrous connective tissue in organs. These agents target the underlying mechanisms involved in fibrosis and help prevent or slow down the progression of the disease.

One commonly used antifibrotic agent is Pirfenidone, which has shown efficacy in treating idiopathic pulmonary fibrosis (IPF). It works by inhibiting the production of pro-inflammatory and fibrotic factors, such as transforming growth factor-beta (TGF-β), platelet-derived growth factor (PDGF), and fibroblast growth factor (FGF). By reducing the levels of these factors, Pirfenidone helps suppress the proliferation and activation of fibroblasts, which are responsible for excessive collagen deposition in fibrotic tissues.

Another antifibrotic agent, Nintedanib, also targets IPF. It is a tyrosine kinase inhibitor that blocks the activity of various growth factor receptors, including PDGF, fibroblast growth factor receptor (FGFR), and vascular endothelial growth factor receptor (VEGFR). By inhibiting these receptors, Nintedanib disrupts the signaling pathways involved in fibrosis, thereby reducing fibroblast activation and collagen production.

These antifibrotic agents have shown promising results in clinical trials and have been approved for the treatment of IPF in several countries. They represent a significant advancement in the management of fibrotic diseases and offer hope to patients by slowing down disease progression and improving overall outcomes.

In conclusion, antifibrotic agents are a vital category of pharmaceutical APIs that target the underlying mechanisms of fibrosis. Through their action on key molecular pathways involved in fibrotic tissue deposition, these agents help reduce the accumulation of fibrous connective tissue and provide potential therapeutic benefits for patients with fibrotic diseases.

• Jubilant Pharmova from India, product country of origin India
• Senova Technology Co., Ltd. from China, product country of origin China
• SETV Global from India, product country of origin India
• Shandong Octagon Chemicals Limited from China, product country of origin China
• Sinoway industrial Co.,Ltd from China, product country of origin China
• Global Pharma Tek from India, product country of origin India
• Chemeca Drugs pvt Ltd from India, product country of origin India
• Laurus Labs from India, product country of origin India
• Chemo Iberica from Spain, product country of origin Spain
• Honour Lab from India, product country of origin India
• ACE Japan from Japan, product country of origin Japan
• Signa from Mexico, product country of origin Mexico
• Raks Pharma from India, product country of origin India
• Rolabo Outsourcing from Spain, product country of origin Spain
• Micro Labs from India, product country of origin India
• Lupin from India, product country of origin India
• ZCL Chemicals from India, product country of origin India
• Cipla from India, product country of origin India
• Mylan from India, product country of origin India
• Procos from Italy, product country of origin Italy
• MSN Pharma from India, product country of origin India
• MSN Life Sciences from India, product country of origin India

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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