Pirfenidone

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Description:

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API | Excipient name:

Pirfenidone 

Synonyms:

 

Cas Number:

53179-13-8 

DrugBank number:

DB04951 

Unique Ingredient Identifier:

D7NLD2JX7U

Pirfenidone is a type of Antifibrotic agents

Antifibrotic agents belong to the pharmaceutical API category that focuses on treating fibrosis, a condition characterized by the excessive accumulation of fibrous connective tissue in organs. These agents target the underlying mechanisms involved in fibrosis and help prevent or slow down the progression of the disease.

One commonly used antifibrotic agent is Pirfenidone, which has shown efficacy in treating idiopathic pulmonary fibrosis (IPF). It works by inhibiting the production of pro-inflammatory and fibrotic factors, such as transforming growth factor-beta (TGF-β), platelet-derived growth factor (PDGF), and fibroblast growth factor (FGF). By reducing the levels of these factors, Pirfenidone helps suppress the proliferation and activation of fibroblasts, which are responsible for excessive collagen deposition in fibrotic tissues.

Another antifibrotic agent, Nintedanib, also targets IPF. It is a tyrosine kinase inhibitor that blocks the activity of various growth factor receptors, including PDGF, fibroblast growth factor receptor (FGFR), and vascular endothelial growth factor receptor (VEGFR). By inhibiting these receptors, Nintedanib disrupts the signaling pathways involved in fibrosis, thereby reducing fibroblast activation and collagen production.

These antifibrotic agents have shown promising results in clinical trials and have been approved for the treatment of IPF in several countries. They represent a significant advancement in the management of fibrotic diseases and offer hope to patients by slowing down disease progression and improving overall outcomes.

In conclusion, antifibrotic agents are a vital category of pharmaceutical APIs that target the underlying mechanisms of fibrosis. Through their action on key molecular pathways involved in fibrotic tissue deposition, these agents help reduce the accumulation of fibrous connective tissue and provide potential therapeutic benefits for patients with fibrotic diseases.

• Shilpa Medicare Ltd from India
• Shandong Octagon Chemicals Limited from China
• TIEFENBACHER API + Ingredients from Germany
• Beijing Hope from China
• Lupin from India
• Rolabo Outsourcing from Spain
• Chemo Iberica from Spain
• Raks Pharma from India
• Laurus Labs from India
• Fabbrica Italiana Sintetici (FIS) from Italy
• Signa from Mexico
• Chemeca Drugs pvt Ltd from India
• Honour Lab from India
• MSN Pharma from India
• Dipharma Francis S.r.l. from Italy
• Jubilant Generics from India
• MSN Life Sciences from India
• Optimus Drugs Pvt Ltd from India
• ZCL Chemicals from India
• Aurobindo from India
• Mylan from India
• Micro Labs from India
• Cipla from India
• Granules India from India
• Alembic Pharma from India
• Pharmazell from Germany
• Glenmark Pharma from India
• Procos from Italy

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