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Established in: 2019
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Looking for Calcium threonate API 70753-61-6?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Calcium threonate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Calcium threonate
- Synonyms:
- Calcium L-threonate , Threonine, calcium salt
- Cas Number:
- 70753-61-6
- DrugBank number:
- DB11168
- Unique Ingredient Identifier:
- HBB4YPO93U
General Description:
Calcium threonate, identified by CAS number 70753-61-6, is a notable compound with significant therapeutic applications. Calcium threonate is a calcium salt of threnoic acid and a novel drug developed for the treatment of osteoporosis and as a calcium supplement . It is found in dietary supplements as a source of L-threonate used in the treatment of calcium deficiency and prevention of osteoporosis. The most common form is calcium L-threonate, or (2R,3S)-2,3,4-trihydroxy butyric acid calcium . L-threonate is an active metabolite of vitamin C that mediates a stimulatory action on vitamin C uptake . Therapeutic efficacy of calcium threonate in reducing was studied and investigated due to the hypothesis that it may play a role in the mineralization process through its positive action on vitamin C.
Indications:
This drug is primarily indicated for: No approved therapeutic indications. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Absorption:
The absorption characteristics of Calcium threonate are crucial for its therapeutic efficacy: Human studies demonstrate that calcium from calcium L-threonate is absorbed . In an open-label, single- and multiple-dose study of healthy adult Chinese subjects receiving a single oral dose of 2025 mg calcium theronate, the peak plasma concentration (Cmax) was 32.3 mg/L . The time to reach peak plasma concentration (Tmax) was approximately 2 hours . The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Calcium threonate is an important consideration for its dosing schedule: The terminal-phase elimination half-life following a single oral dose of 2025 mg calcium theronate in healthy adult Chinese subjects was approximately 2.7 hours . This determines the duration of action and helps in formulating effective dosing regimens.
Route of Elimination:
The elimination of Calcium threonate from the body primarily occurs through: The presence of threonic acid in human urine has been identified . In a pharmacokinetic study of rats receiving 200 mg/kg bw of calcium threonate orally, approximately 30% of the calcium was excreted in the urine, around 40% was eliminated in the faeces, and about 10 -20% remained in the blood and bone, and about 10% was stored in organs after 24 hours of administration . Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Calcium threonate is distributed throughout the body with a volume of distribution of: The apparent total volume of distribution following a single oral dose of 2025 mg calcium theronate in healthy adult Chinese subjects was approximately 53.6 L . This metric indicates how extensively the drug permeates into body tissues.
Clearance:
The clearance rate of Calcium threonate is a critical factor in determining its safe and effective dosage: Apparent total clearance following a single oral dose of 2025 mg calcium theronate in healthy adult Chinese subjects was approximately 14.5 L/h . It reflects the efficiency with which the drug is removed from the systemic circulation.
Pharmacodynamics:
Calcium threonate exerts its therapeutic effects through: In a preclinical study, calcium L-theronate inhibited the bone resorption of osteoclasts _in vitro_ . The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Calcium threonate functions by: Once dissociated to calcium and L-theronic acid, L-threonic acid exhibits significant stimulatory action on vitamin C uptake and prolongs the retention of vitamin C in human T-lymphoma cells . Vitamin C is a marker for osteoblast formation and has been shown to stimulate procollagen and enhance collagen synthesis . Via stimulation of vitamin C uptake, L-threonic acid acts as a metabolite that influences the mineralization process . This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Toxicity:
Classification:
Calcium threonate belongs to the class of organic compounds known as sugar acids and derivatives. These are compounds containing a saccharide unit which bears a carboxylic acid group, classified under the direct parent group Sugar acids and derivatives. This compound is a part of the Organic compounds, falling under the Organic oxygen compounds superclass, and categorized within the Organooxygen compounds class, specifically within the Carbohydrates and carbohydrate conjugates subclass.
Categories:
Calcium threonate is categorized under the following therapeutic classes: Acids, Acyclic, Fatty Acids, Fatty Acids, Volatile, Lipids. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Calcium threonate include:
- Water Solubility: Soluble
- Melting Point: >300
Calcium threonate is a type of Antimetabolites
Antimetabolites are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various diseases, particularly cancer. These compounds are structurally similar to naturally occurring metabolites essential for cellular processes such as DNA and RNA synthesis. By mimicking these metabolites, antimetabolites interfere with the normal functioning of cellular pathways, leading to inhibition of cancer cell growth and proliferation.
One of the widely used antimetabolites is methotrexate, a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, disrupting the production of DNA and RNA. This disruption impedes the growth of rapidly dividing cancer cells. Another common antimetabolite is 5-fluorouracil (5-FU), which inhibits the enzyme thymidylate synthase, thereby interfering with DNA synthesis and inhibiting cancer cell proliferation.
Antimetabolites can be classified into several subcategories based on their mechanism of action and chemical structure. These include purine and pyrimidine analogs, folic acid antagonists, and pyrimidine synthesis inhibitors. Examples of antimetabolites in these subcategories include azathioprine, cytarabine, and gemcitabine.
Despite their effectiveness, antimetabolites can exhibit certain side effects due to their interference with normal cellular processes. These side effects may include gastrointestinal disturbances, myelosuppression (reduced production of blood cells), and hepatotoxicity.
In conclusion, antimetabolites are a vital category of pharmaceutical APIs used in the treatment of various diseases, especially cancer. By mimicking natural metabolites and disrupting crucial cellular processes, these compounds effectively inhibit cancer cell growth and proliferation. However, their usage should be carefully monitored due to potential side effects.
Calcium threonate manufacturers | traders | suppliers
We have 1 companies offering Calcium threonate produced in 1 different countries.
Get in contact with the supplier of your choice:
- Aurora Industry Co., Ltd from China, product country of origin China
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