Capecitabine

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Description:

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API | Excipient name:

Capecitabine 

Synonyms:

Capecitabin , Capecitabina , Capecitabinum , Xeloda  

Cas Number:

154361-50-9 

DrugBank number:

DB01101 

Unique Ingredient Identifier:

6804DJ8Z9U

Capecitabine is a type of Antimetabolites

Antimetabolites are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various diseases, particularly cancer. These compounds are structurally similar to naturally occurring metabolites essential for cellular processes such as DNA and RNA synthesis. By mimicking these metabolites, antimetabolites interfere with the normal functioning of cellular pathways, leading to inhibition of cancer cell growth and proliferation.

One of the widely used antimetabolites is methotrexate, a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, disrupting the production of DNA and RNA. This disruption impedes the growth of rapidly dividing cancer cells. Another common antimetabolite is 5-fluorouracil (5-FU), which inhibits the enzyme thymidylate synthase, thereby interfering with DNA synthesis and inhibiting cancer cell proliferation.

Antimetabolites can be classified into several subcategories based on their mechanism of action and chemical structure. These include purine and pyrimidine analogs, folic acid antagonists, and pyrimidine synthesis inhibitors. Examples of antimetabolites in these subcategories include azathioprine, cytarabine, and gemcitabine.

Despite their effectiveness, antimetabolites can exhibit certain side effects due to their interference with normal cellular processes. These side effects may include gastrointestinal disturbances, myelosuppression (reduced production of blood cells), and hepatotoxicity.

In conclusion, antimetabolites are a vital category of pharmaceutical APIs used in the treatment of various diseases, especially cancer. By mimicking natural metabolites and disrupting crucial cellular processes, these compounds effectively inhibit cancer cell growth and proliferation. However, their usage should be carefully monitored due to potential side effects.

• Shilpa Medicare Ltd from India
• Avanscure Lifesciences Pvt Ltd from India
• SENOVA Technology Co., Ltd. from China
• TIEFENBACHER API + Ingredients from Germany
• Shandong Boyuan from China
• Euticals from Italy
• Excella from Germany
• Laurus Labs from India
• Shanghai Jinhe Bio-Pharma from China
• Acebright Pharma from India
• Intas Pharma from United Kingdom
• Zhejiang Hisun Pharma from China
• Fareva from France
• Socosur from France
• Mac Chem Products from India
• Reliance Life Sciences from India
• Qilu Tianhe from China
• Signa from Mexico
• Adley Formulations from India
• Mylan from India
• Sun Pharma from India
• Dr. Reddy's from India
• Shaoxing Hantai Pharma from China
• Divis Labs. from India
• MSN Labs. from India
• Cipla from India
• Granules India from India
• Hetero Labs from India

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