Cytarabine API Manufacturers

Looking for Cytarabine API 147-94-4?

Description:

Here you will find a list of producers, manufacturers and distributors of Cytarabine. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Cytarabine 

Synonyms:

Ara-C , Arabinofuranosyl Cytidine , Citarabina , Cytarabine , Cytarabinum , Cytosine arabinoside , Cytosine-1-beta-D-arabinofuranoside , Cytosine-beta-D-arabinofuranoside  

Cas Number:

147-94-4 

DrugBank number:

DB00987 

Unique Ingredient Identifier:

04079A1RDZ

Cytarabine is a type of Antimetabolites

Antimetabolites are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various diseases, particularly cancer. These compounds are structurally similar to naturally occurring metabolites essential for cellular processes such as DNA and RNA synthesis. By mimicking these metabolites, antimetabolites interfere with the normal functioning of cellular pathways, leading to inhibition of cancer cell growth and proliferation.

One of the widely used antimetabolites is methotrexate, a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, disrupting the production of DNA and RNA. This disruption impedes the growth of rapidly dividing cancer cells. Another common antimetabolite is 5-fluorouracil (5-FU), which inhibits the enzyme thymidylate synthase, thereby interfering with DNA synthesis and inhibiting cancer cell proliferation.

Antimetabolites can be classified into several subcategories based on their mechanism of action and chemical structure. These include purine and pyrimidine analogs, folic acid antagonists, and pyrimidine synthesis inhibitors. Examples of antimetabolites in these subcategories include azathioprine, cytarabine, and gemcitabine.

Despite their effectiveness, antimetabolites can exhibit certain side effects due to their interference with normal cellular processes. These side effects may include gastrointestinal disturbances, myelosuppression (reduced production of blood cells), and hepatotoxicity.

In conclusion, antimetabolites are a vital category of pharmaceutical APIs used in the treatment of various diseases, especially cancer. By mimicking natural metabolites and disrupting crucial cellular processes, these compounds effectively inhibit cancer cell growth and proliferation. However, their usage should be carefully monitored due to potential side effects.

• Shandong Octagon Chemicals Limited from China, product country of origin China
• Euticals from Italy, product country of origin Unknown
• Zhejiang Hisun Pharma from China, product country of origin China
• Ferro Pfanstiehl Labs. from United States, product country of origin United States
• Avanscure Lifesciences Pvt Ltd from India, product country of origin India
• Mac Chem Products from India, product country of origin India
• Asahi Kasei from Japan, product country of origin Japan

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