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Produced in:
Established in: 1968
MOQ: 1 kg
Employees: 50+
Warehouse stock of nearly all APIs
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Looking for Mercaptopurine API 50-44-2?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Mercaptopurine. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Mercaptopurine
- Synonyms:
- 6-Thioxopurine , Mercaptopurina , mercaptopurinum , Mercapurin
- Cas Number:
- 50-44-2
- DrugBank number:
- DB01033
- Unique Ingredient Identifier:
- PKK6MUZ20G
About Mercaptopurine
Want to know what Mercaptopurine is used for? An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
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Mercaptopurine is a type of Antimetabolites
Antimetabolites are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various diseases, particularly cancer. These compounds are structurally similar to naturally occurring metabolites essential for cellular processes such as DNA and RNA synthesis. By mimicking these metabolites, antimetabolites interfere with the normal functioning of cellular pathways, leading to inhibition of cancer cell growth and proliferation.
One of the widely used antimetabolites is methotrexate, a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, disrupting the production of DNA and RNA. This disruption impedes the growth of rapidly dividing cancer cells. Another common antimetabolite is 5-fluorouracil (5-FU), which inhibits the enzyme thymidylate synthase, thereby interfering with DNA synthesis and inhibiting cancer cell proliferation.
Antimetabolites can be classified into several subcategories based on their mechanism of action and chemical structure. These include purine and pyrimidine analogs, folic acid antagonists, and pyrimidine synthesis inhibitors. Examples of antimetabolites in these subcategories include azathioprine, cytarabine, and gemcitabine.
Despite their effectiveness, antimetabolites can exhibit certain side effects due to their interference with normal cellular processes. These side effects may include gastrointestinal disturbances, myelosuppression (reduced production of blood cells), and hepatotoxicity.
In conclusion, antimetabolites are a vital category of pharmaceutical APIs used in the treatment of various diseases, especially cancer. By mimicking natural metabolites and disrupting crucial cellular processes, these compounds effectively inhibit cancer cell growth and proliferation. However, their usage should be carefully monitored due to potential side effects.
Mercaptopurine manufacturers | traders | suppliers
We have 6 companies offering Mercaptopurine produced in 5 different countries.
Get in contact with the supplier of your choice:
- Duchefa Farma B.V. from Netherlands, product country of origin Brazil
- Ajinomoto from Japan, product country of origin Japan
- Humble Healthcaare from India, product country of origin India
- Zhejiang Chengyi from China, product country of origin China
- Surajlok Chemicals from India, product country of origin India
- Fermion from Finland, product country of origin Finland
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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