Methotrexate API Manufacturers

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Located in:

India

Produced in:

India

Established in: 2012

MOQ: 1 kg

Employees: 50+

Diverse portfolio of APIs and Nutra products

Focus on Hormones Oncology and Peptides with the highest quality

Leading manufacturer of ALpha Lipoic Acid

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • CoA

  • MSDS

  • GMP

  • ISO9001

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Replies quickly

Located in:

China

Engaged in the production of small molecule chemical drug APIs and preparations

Provide CDMO services for high-activity anti-tumor characteristic APIs

153-acre API and preparation production base

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • GMP

  • CoA

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Replies quickly

Produced in:

China

Established in: 1923

MOQ: 25 kg

Employees: 20+

Service-oriented company

Global supply chain resilience

Support of your new projects from start to commercial realisation

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • WC

  • GMP

  • CoA

  • MSDS

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Replies quickly

Located in:

China
Contact supplier

Replies slower than most

Located in:

Hungary

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • CEP

  • coa

  • GMP

  • FDA

  • DMF

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Replies slower than most

Located in:

China
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • WC

  • CoA

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Replies slower than most

Located in:

Hungary
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • coa

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Replies slower than most

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • WC

  • CoA

  • GMP

Contact supplier

Replies slower than most

Located in:

China
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • FDA

  • WC

  • JDMF

  • CEP

  • coa

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Replies slower than most

Located in:

China
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • WC

  • coa

  • CEP

  • DMF

  • GMP

Contact supplier

Replies slower than most

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • ISO 9001

  • CoA

Contact supplier

Replies slower than most

Located in:

Finland

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • GMP

  • GDP

  • JMF

  • JDMF

  • CoA

  • BSE/TSE

  • CEP

  • DMF

  • MSDS

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Looking for Methotrexate API 59-05-2?

Description:
Here you will find a list of producers, manufacturers and traders of Methotrexate. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:
Methotrexate 
Synonyms:
Amethopterin , Emtexate , Ledertrexate , Methotrexat , Methotrexatum , Metotrexato , MTX , Rheumatrex , Trexall  
Cas Number:
59-05-2 
DrugBank number:
DB00563 
Unique Ingredient Identifier:
YL5FZ2Y5U1

About Methotrexate

Why are people looking for Methotrexate? Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments.

You can ask the supplier about all relevant certificates for the product such as CoA, Safety Data Sheet and DMF.

Methotrexate is a type of Antimetabolites


Antimetabolites are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various diseases, particularly cancer. These compounds are structurally similar to naturally occurring metabolites essential for cellular processes such as DNA and RNA synthesis. By mimicking these metabolites, antimetabolites interfere with the normal functioning of cellular pathways, leading to inhibition of cancer cell growth and proliferation.

One of the widely used antimetabolites is methotrexate, a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, disrupting the production of DNA and RNA. This disruption impedes the growth of rapidly dividing cancer cells. Another common antimetabolite is 5-fluorouracil (5-FU), which inhibits the enzyme thymidylate synthase, thereby interfering with DNA synthesis and inhibiting cancer cell proliferation.

Antimetabolites can be classified into several subcategories based on their mechanism of action and chemical structure. These include purine and pyrimidine analogs, folic acid antagonists, and pyrimidine synthesis inhibitors. Examples of antimetabolites in these subcategories include azathioprine, cytarabine, and gemcitabine.

Despite their effectiveness, antimetabolites can exhibit certain side effects due to their interference with normal cellular processes. These side effects may include gastrointestinal disturbances, myelosuppression (reduced production of blood cells), and hepatotoxicity.

In conclusion, antimetabolites are a vital category of pharmaceutical APIs used in the treatment of various diseases, especially cancer. By mimicking natural metabolites and disrupting crucial cellular processes, these compounds effectively inhibit cancer cell growth and proliferation. However, their usage should be carefully monitored due to potential side effects.

Methotrexate manufacturers | traders | suppliers

We have 12 companies offering Methotrexate produced in 4 different countries.

Get in contact with the supplier of your choice:

  • Avanscure Lifesciences Pvt Ltd from India, product country of origin India
  • Sichuan Elixir Pharmaceutical Co., Ltd from China, product country of origin China
  • Otto Brandes GmbH from Germany, product country of origin China
  • Shanghai Jinhe Bio-Pharma from China, product country of origin China
  • CF Pharma from Hungary, product country of origin Hungary
  • Zhejiang Haizhou from China, product country of origin China
  • Patriapharma from Hungary, product country of origin Hungary
  • Mac Chem Products from India, product country of origin India
  • Huzhou Zhanwang from China, product country of origin China
  • Zhejiang Hisun Pharma from China, product country of origin China
  • Suryakala Laboratories Pvt Ltd from India, product country of origin India
  • Fermion from Finland, product country of origin Finland

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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