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Buspirone
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Established in: 2005
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Looking for Buspirone API 36505-84-7?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Buspirone. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Buspirone
- Synonyms:
- Buspiron , Buspirona , Buspirone , Buspironum
- Cas Number:
- 36505-84-7
- DrugBank number:
- DB00490
- Unique Ingredient Identifier:
- TK65WKS8HL
About Buspirone
What can you use it for? Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, buspirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Due to these characteristics, buspirone been termed 'anxioselective'.
First synthesized in 1968 then patented in 1975 it is commonly marketed under the brand name Buspar®. Buspirone was first approved in 1986 by the FDA 4 and has been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin reuptake inhibitors (SSRIs) is deemed clinically inadequate or inappropriate. The potential use of buspirone in combination with melatonin in depression and cognitive impairment via promoting neurogenesis has also been investigated.
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Buspirone is a type of Anxiolytics
Anxiolytics, belonging to the pharmaceutical API (Active Pharmaceutical Ingredient) category, are substances utilized in the development of drugs aimed at treating anxiety disorders. Anxiety disorders are prevalent mental health conditions characterized by excessive worry, fear, and unease. Anxiolytics work by modulating certain neurotransmitters in the brain, such as gamma-aminobutyric acid (GABA), which plays a crucial role in reducing neuronal excitability and inducing a calming effect.
These pharmaceutical APIs have revolutionized the management of anxiety disorders, providing relief to millions of individuals worldwide. Anxiolytics can be further classified into various subcategories based on their mechanism of action, including benzodiazepines, selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and others.
Benzodiazepines, the most commonly prescribed anxiolytics, enhance the activity of GABA receptors, thereby producing sedative and hypnotic effects. SSRIs and SNRIs, on the other hand, primarily work by increasing the availability of serotonin and norepinephrine, respectively, in the brain, leading to a positive impact on mood and anxiety.
The development and production of anxiolytics involve stringent quality control measures to ensure their safety and efficacy. Pharmaceutical companies adhere to Good Manufacturing Practices (GMP) guidelines and conduct thorough preclinical and clinical trials to evaluate the compound's pharmacokinetics, efficacy, and adverse effects.
In conclusion, anxiolytics are a crucial category of pharmaceutical APIs used to address anxiety disorders. Through their modulation of neurotransmitters and receptors in the brain, these medications effectively alleviate symptoms and improve the quality of life for individuals affected by anxiety.
Buspirone manufacturers | traders | suppliers
We have 4 companies offering Buspirone produced in 3 different countries.
Get in contact with the supplier of your choice:
- LGM Pharma from United States, product country of origin World
- Unichem Labs. from India, product country of origin India
- Unimark Remedies from India, product country of origin India
- Fermion from Finland, product country of origin Finland
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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