Letrozole

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API | Excipient name:

Letrozole 

Synonyms:

Femara , Letrozol , Letrozole  

Cas Number:

112809-51-5 

DrugBank number:

DB01006 

Unique Ingredient Identifier:

7LKK855W8I

Letrozole is a type of Aromatase inhibitors

Aromatase inhibitors (AIs) are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) commonly used in the treatment of hormone-sensitive conditions, including breast cancer and endometriosis. These compounds work by blocking the enzyme aromatase, which is responsible for the conversion of androgens into estrogens in peripheral tissues.

AIs are classified into two main types: steroidal and non-steroidal inhibitors. Steroidal AIs, such as exemestane, bind irreversibly to aromatase, while non-steroidal AIs, such as anastrozole and letrozole, inhibit aromatase activity reversibly. Both types effectively reduce estrogen levels, which is beneficial in hormone-driven cancers where estrogen promotes tumor growth.

The use of AIs in breast cancer treatment has significantly improved patient outcomes, particularly in postmenopausal women. By suppressing estrogen production, AIs prevent estrogen from fueling the growth of estrogen receptor-positive breast cancer cells. They are often prescribed as adjuvant therapy after surgery or as a first-line treatment for metastatic breast cancer.

Apart from their application in breast cancer, AIs have also shown efficacy in managing endometriosis, a painful condition where endometrial tissue grows outside the uterus. By reducing estrogen levels, AIs help alleviate symptoms and inhibit the growth of endometrial lesions.

Overall, aromatase inhibitors are vital components of modern pharmaceutical therapies targeting hormone-related diseases. Their ability to modulate estrogen levels through enzymatic inhibition has revolutionized the treatment landscape for breast cancer and endometriosis, improving patient prognosis and quality of life.

Letrozole (Aromatase inhibitors), classified under Hormonal Agents

Hormonal agents are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) widely used in the medical field. These substances play a crucial role in regulating and modulating hormonal functions within the body. Hormonal agents are designed to mimic or manipulate the effects of naturally occurring hormones, allowing healthcare professionals to treat various endocrine disorders and hormonal imbalances.

Hormonal agents are commonly employed in the treatment of conditions such as hypothyroidism, hyperthyroidism, diabetes, and hormonal cancers. These APIs work by interacting with specific hormone receptors, either by stimulating or inhibiting their activity, to restore the balance of hormones in the body. They can be administered orally, intravenously, or through other routes depending on the specific medication and patient needs.

Pharmaceutical companies employ rigorous manufacturing processes and quality control measures to ensure the purity, potency, and safety of hormonal agent APIs. These APIs are synthesized using chemical or biotechnological methods, often starting from natural hormone sources or through recombinant DNA technology. Stringent regulatory guidelines are in place to guarantee the efficacy and safety of hormonal agent APIs, ensuring that patients receive high-quality medications.

As the demand for hormone-related therapies continues to grow, ongoing research and development efforts focus on enhancing the effectiveness and reducing the side effects of hormonal agent APIs. This includes the exploration of novel delivery systems, advanced formulations, and targeted drug delivery methods. By continuously advancing our understanding and capabilities in hormonal agents, the medical community can improve patient outcomes and quality of life for individuals with hormonal disorders.

• Shilpa Medicare Ltd from India
• LGM Pharma from United States
• Shandong Octagon Chemicals Limited from China
• Actavis Group from Iceland
• USV from India
• Teva API from Israel
• Finorga from France
• ALCAMI from United States
• Natco Pharma from India
• Ind-Swift Labs. from India
• Mac Chem Products from India
• Fresenius Kabi Onc. from India
• Humble Healthcaare from India
• Zhejiang Hisun Pharma from China
• Fujian South Pharma from China
• Jiangsu Hengrui from China
• Sun Pharma from India
• Hetero Labs from India
• Mylan from India
• Dr. Reddy's from India
• Cipla from India
• Health Options Europe from United Kingdom

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