Tacrolimus API Manufacturers

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Located in:

China

Produced in:

China

Established in: 1987

MOQ: 1 kg

Passed ISO9001:2015 and SGS audit

Provide one-stop CDMO service from R&D to production

Certifications: ISO9001: 2015, HALAL Certificate, Kosher Certification

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HIGHLIGHTED

Located in:

China

Produced in:

China

Established in: 2011

MOQ: 100 g

Employees: 10+

Fast Response and Good Communication

Willingness To Start From Small

Flexible Payment Terms

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HIGHLIGHTED

Located in:

China

Produced in:

China

Established in: 2005

MOQ: 10 g

Employees: 85

Strict quality control

15 years of experience in API production

Provide OEM & ODM service

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HIGHLIGHTED

Located in:

China

Produced in:

China

Established in: 2013

MOQ: 1 kg

Employees: 25+

ISO9001 certified

Drug R&D center (in Hangzhou)

From lab scale (mg/g) to commercial scale (kgs/tons)

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Produced in:

Unknown

Established in: 1963

MOQ: -

Employees: 800+

World’s 1st exclusive API distributor

Portfolio of 600+ APIs

>250 clients in Europe

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Produced in:

India

Established in: 1968

MOQ: 25 g

Employees: 50+

Warehouse stock of nearly all APIs

GMP, GDP and ISO certified

Customisable (small-sized) packages

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Located in:

Germany

Distributor

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Replies slower than most

Located in:

Japan
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Producer

Produced in:

India

Established in: 1995

MOQ: -

Employees: 10000

Fermentation technology Experts

Partnerships with 1200 pharma companies in 100+ countries

US FDA, EMA, COFEPRIES, ANVISA, PMDA accreditations

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Producer

Produced in:

Unknown

Established in: 1944

MOQ: -

Employees: 4,000

14 international API plant sites

Portfolio of 350+ APIs

Teva is among the world’s largest generic drug/API manufacturers

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Located in:

India

Distributor

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Located in:

India
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Located in:

India
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Located in:

Italy

Producer

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Located in:

China
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Located in:

China
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Located in:

South Korea

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Located in:

Slovenia

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Located in:

China
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Looking for Tacrolimus API 104987-11-3?

Description:
Here you will find a list of producers, manufacturers and traders of Tacrolimus. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:
Tacrolimus 
Synonyms:
Anhydrous tacrolimus , Tacrolimus anhydrous , Tacrolimus , anhydrous  
Cas Number:
104987-11-3 
DrugBank number:
DB00864 
Unique Ingredient Identifier:
Y5L2157C4J

About Tacrolimus

Want to know more about Tacrolimus? Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide.

It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 transcription.

Check who is selling Tacrolimus in the overview above.

Tacrolimus is a type of Calcineurin inhibitors


Calcineurin inhibitors are a vital subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs) widely used in the treatment of various medical conditions. These inhibitors work by suppressing the activity of calcineurin, an enzyme that plays a crucial role in the immune response.

The primary application of calcineurin inhibitors is in the field of immunosuppression, particularly in organ transplantation. These medications prevent the rejection of transplanted organs by inhibiting the production of cytokines, such as interleukin-2, which are responsible for triggering the immune response. By modulating the immune system, calcineurin inhibitors enable successful transplantation and enhance patient outcomes.

Furthermore, calcineurin inhibitors find utility in the treatment of autoimmune disorders, including psoriasis and rheumatoid arthritis. These medications help alleviate symptoms and reduce inflammation by interfering with the immune system's response.

The two most commonly used calcineurin inhibitors are cyclosporine and tacrolimus. These compounds exhibit high specificity and affinity for calcineurin, ensuring effective immunosuppression. Both drugs are available in various formulations, including oral capsules, injectables, and topical preparations, enabling healthcare professionals to tailor treatment to individual patient needs.

It is important to note that calcineurin inhibitors may have certain side effects, including nephrotoxicity, hypertension, and increased susceptibility to infections. Close monitoring of patients and appropriate dosage adjustments are crucial to maintaining the delicate balance between immune suppression and overall health.

In summary, calcineurin inhibitors represent a vital subcategory of pharmaceutical APIs used in immunosuppressive therapy for organ transplantation and autoimmune disorders. Their ability to modulate the immune response plays a crucial role in achieving successful patient outcomes.


Tacrolimus (Calcineurin inhibitors), classified under Dermatological Agents


Dermatological agents are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) used in the formulation of various skincare and dermatology products. These APIs are specifically designed to target and treat skin conditions, offering effective solutions for a wide range of dermatological concerns.

Dermatological agents encompass a diverse array of compounds, including corticosteroids, antifungal agents, antibacterials, retinoids, and immunomodulators. Each API within this category possesses unique properties and mechanisms of action, enabling them to address specific skin-related issues.

Corticosteroids, for instance, are potent anti-inflammatory agents commonly used in the treatment of skin conditions like eczema, psoriasis, and dermatitis. Antifungal agents, on the other hand, combat fungal infections such as athlete's foot or ringworm. Antibacterials are effective against bacterial infections, while retinoids promote skin cell turnover and treat acne and photoaging. Immunomodulators regulate the immune response, providing relief from conditions like atopic dermatitis.

The development and application of dermatological APIs involve rigorous research, clinical trials, and regulatory compliance. These APIs are typically integrated into topical creams, ointments, gels, and lotions, ensuring targeted delivery to the affected areas of the skin.

Dermatological agents play a crucial role in the management and treatment of various skin disorders. By harnessing the therapeutic properties of these APIs, pharmaceutical companies can develop innovative skincare products that cater to the diverse needs of individuals seeking effective dermatological solutions.



Tacrolimus manufacturers | traders | suppliers

We have 19 companies offering Tacrolimus produced in 6 different countries.

Get in contact with the supplier of your choice:

  • Sinoway industrial Co.,Ltd from China, product country of origin China
  • Shandong Octagon Chemicals Limited from China, product country of origin China
  • Xi'an Tian Guangyuan Biotech Co.,Ltd from China, product country of origin China
  • Senova Technology Co., Ltd. from China, product country of origin China
  • TIEFENBACHER API + Ingredients from Germany, product country of origin Unknown
  • Duchefa Farma B.V. from Netherlands, product country of origin India
  • Flavine from Germany, product country of origin Unknown
  • Astellas Pharma from Japan, product country of origin Japan
  • Biocon from India, product country of origin India
  • Teva API from Israel, product country of origin Unknown
  • Kromozome from India, product country of origin India
  • Stilbene Biopharma from India, product country of origin India
  • Murli Krishna Pharma Pvt. Ltd from India, product country of origin India
  • Euticals from Italy, product country of origin Italy
  • Hangzhou Zhongmei Huadong from China, product country of origin China
  • Fujian Kerui from China, product country of origin China
  • CKD Bio from South Korea, product country of origin South Korea
  • Lek Pharma from Slovenia, product country of origin India
  • Shaoxing Hantai Pharma from China, product country of origin China

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