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Magnesium cation | CAS No: 22537-22-0 | GMP-certified suppliers
A medication that provides osmotic laxative effects to relieve constipation and serves as an antacid for managing indigestion and heartburn in gastrointestinal care.
Therapeutic categories
Product Snapshot
- Magnesium cation is available in oral formulation types including tablets, effervescent tablets, and granules
- Its primary therapeutic uses include supplementation for magnesium deficiency and related mineral balance support
- It is approved as a nutraceutical product in key regulatory markets
Clinical Overview
Pharmacologically, magnesium hydroxide acts as an osmotic agent within the gastrointestinal tract. Upon oral administration, it retains and draws water into the intestinal lumen by exerting osmotic pressure. This fluid retention distends the bowel, which subsequently stimulates the enteric nerves in the colon wall, promoting peristalsis and facilitating the evacuation of intestinal contents. This osmotic activity also affects fluid and electrolyte movement along both small and large intestines, modulating absorption and secretion processes.
The mechanism involves polyvalent magnesium cations influencing intestinal electrolyte balance and motility. Magnesium ions participate in neuromuscular transmission and can indirectly contribute to neuromuscular blockade at higher concentrations. Additionally, magnesium hydroxide’s alkalinity enables it to neutralize gastric acid, offering antacid effects.
Key ADME characteristics involve minimal systemic absorption of magnesium hydroxide at the doses typically used for laxative or antacid purposes. The majority remains within the gastrointestinal tract, with excretion primarily via fecal elimination. When absorbed, magnesium is metabolized and excreted by renal pathways, necessitating caution in patients with compromised kidney function due to risks of hypermagnesemia.
Safety considerations include potential electrolyte imbalance, dehydration, and gastrointestinal irritation with excessive use. Patients with renal insufficiency or cardiovascular conditions should use magnesium-containing products under medical supervision. Notable usage contexts include over-the-counter formulations for symptomatic relief of constipation and acidity.
From a sourcing and quality standpoint, magnesium hydroxide APIs require stringent control of purity, particle size, and heavy metal contaminants given their direct gastrointestinal application. Manufacturers must adhere to pharmacopeial standards such as USP and EP to ensure consistent osmotic activity and safety profiles. Reliable supply chains and comprehensive analytical characterization are critical for pharmaceutical-grade magnesium hydroxide used in clinical and nutraceutical products.
Identification & chemistry
| Generic name | Magnesium cation |
|---|---|
| Molecule type | Small molecule |
| CAS | 22537-22-0 |
| UNII | T6V3LHY838 |
| DrugBank ID | DB01378 |
Pharmacology
Targets
| Target | Organism | Actions |
|---|---|---|
| Sodium/potassium-transporting ATPase subunit alpha-1 | Humans |
Formulation & handling
- Magnesium cation is formulated primarily for oral administration in solid dosage forms such as tablets and effervescent granules.
- As a small inorganic molecule, it exhibits good stability under standard handling conditions with no specific sensitivity to food reported.
- Effervescent formulations require consideration of excipient compatibility and packaging to maintain stability and dissolution performance.
Regulatory status
Supply Chain
| Supply chain summary | The supply landscape for magnesium cation involves multiple originator companies acting as packagers, indicating a diverse manufacturing base. Branded products have a global presence, notably in the US, EU, and other regions, reflecting widespread market availability. Patent expiry has allowed for established generic competition, supporting broad access to this API across various markets. |
|---|
Magnesium is a type of Calcium regulators
Calcium regulators are a vital subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs) used in the field of medicine. These compounds play a crucial role in maintaining the balance of calcium levels within the body. Calcium is an essential mineral that participates in numerous physiological processes, including muscle contraction, nerve transmission, and bone health.
Pharmaceutical APIs classified as calcium regulators are designed to modulate the levels of calcium in the body, either by increasing or decreasing its concentration as needed. These APIs act by targeting specific mechanisms involved in calcium regulation, such as calcium channels, transporters, or enzymes.
Calcium regulators find application in the treatment of various medical conditions. For instance, drugs that promote calcium absorption or enhance bone mineral density can be employed to manage osteoporosis, a condition characterized by weak and brittle bones. Conversely, medications that inhibit calcium channels or reduce calcium levels are used in the treatment of conditions like hypertension or cardiac arrhythmias.
The development of calcium regulators involves extensive research and rigorous testing to ensure their safety and efficacy. Pharmaceutical companies invest significant resources in the discovery, synthesis, and optimization of these APIs. Additionally, regulatory authorities closely monitor the production and distribution of calcium regulators to ensure compliance with stringent quality standards.
In summary, calcium regulators are a specialized category of pharmaceutical APIs that play a crucial role in maintaining calcium balance within the body. These compounds are integral to the treatment of various medical conditions and require rigorous research and testing to ensure their effectiveness and safety.
Magnesium (Calcium regulators), classified under Metabolic Bone Disease Agents
Metabolic Bone Disease Agents are a category of pharmaceutical active pharmaceutical ingredients (APIs) that are specifically designed to treat and manage conditions related to the bones and their metabolism. These agents play a crucial role in the treatment of various metabolic bone diseases, including osteoporosis, Paget's disease, and rickets.
The primary function of Metabolic Bone Disease Agents is to regulate bone remodeling and maintain bone health. They achieve this by targeting specific pathways involved in bone metabolism, such as osteoclast and osteoblast activity, calcium regulation, and vitamin D metabolism.
These APIs are commonly used in the development of medications, including oral tablets, injectables, and topical formulations, for the effective treatment of metabolic bone diseases. They are carefully formulated to optimize their pharmacokinetic and pharmacodynamic properties, ensuring maximum efficacy and minimal side effects.
Metabolic Bone Disease Agents encompass a range of substances, including bisphosphonates, selective estrogen receptor modulators (SERMs), calcitonin, and vitamin D analogs. These APIs act through different mechanisms to address specific aspects of bone health, such as inhibiting bone resorption, promoting bone formation, or regulating calcium levels.
In conclusion, Metabolic Bone Disease Agents are a vital category of pharmaceutical APIs used in the development of medications for the treatment and management of various metabolic bone diseases. These agents target specific pathways involved in bone metabolism to regulate bone remodeling, enhance bone health, and alleviate the symptoms associated with these conditions.
Magnesium API manufacturers & distributors
Compare qualified Magnesium API suppliers worldwide. We currently have 9 companies offering Magnesium API, with manufacturing taking place in 5 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Anjan Drugs | Producer | India | India | CoA, GMP, WC | 4 products |
| Anmol Chemicals | Producer | India | India | CoA | 7 products |
| InventyS Research Company... | Producer | India | India | CoA | 5 products |
| Jost Chemical | Producer | United States | United States | CoA | 14 products |
| JQC (Huayin) Pharmaceutic... | Producer | China | China | CoA | 8 products |
| Organotechnie | Producer | France | Unknown | CEP, CoA, GMP | 2 products |
| Ruibang Laboraties | Producer | China | China | CoA, FDA, GMP | 10 products |
| Sun Pharma | Producer | India | India | CoA, GMP, WC | 219 products |
| Tomita Pharmaceutical | Producer | Japan | Japan | CoA, JDMF | 10 products |
When sending a request, specify which Magnesium API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Magnesium API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
