Fluprednidene acetate API Manufacturers & Suppliers
2 verified results
Commercial-scale Suppliers
All certificates
All certificates







Fluprednidene acetate | CAS No: 1255-35-2 | GMP-certified suppliers
A medication that provides anti-inflammatory and anti-allergic effects for research into corticosteroid applications in immune-related and inflammatory conditions.
Therapeutic categories
Product Snapshot
- Fluprednidene acetate is a topical corticosteroid formulation available as creams and ointments
- It is primarily used for anti-inflammatory and anti-pruritic applications in dermatology
- The compound is currently in an experimental approval status and not yet authorized in major regulatory markets
Clinical Overview
Despite the absence of detailed pharmacodynamic and mechanism of action data specific to fluprednidene acetate, it can be inferred that its mode of action involves modulation of the glucocorticoid receptor, leading to transcriptional regulation of inflammatory mediators and suppression of immune responses. This is consistent with the known pharmacology of corticosteroids acting as adrenal cortex hormones.
Fluprednidene acetate is also identified as an inducer of several cytochrome P450 enzymes, notably CYP3A4 and CYP3A5 isoforms. This enzymatic induction can influence the metabolism of concomitant medications, posing considerations for drug-drug interactions during clinical development or experimental use.
Data regarding absorption, distribution, metabolism, and excretion (ADME) parameters for fluprednidene acetate have not been disclosed. Similarly, specific safety and toxicity profiles remain uncharacterized, necessitating cautious evaluation in preclinical and clinical investigations.
Currently, there are no notable commercial brands or approved therapeutic uses associated with fluprednidene acetate. As an experimental steroidal compound, it may be utilized primarily in research and formulation development settings.
In terms of API procurement, sourcing fluprednidene acetate requires attention to rigorous quality standards adhering to Good Manufacturing Practices (GMP). Verification of chemical purity, stereochemical integrity, and absence of impurities is critical to ensure reproducibility and compliance with regulatory demands for corticosteroid APIs. Given its experimental status, working with established, reliable suppliers with transparent documentation and certification is recommended.
Identification & chemistry
| Generic name | Fluprednidene acetate |
|---|---|
| Molecule type | Small molecule |
| CAS | 1255-35-2 |
| UNII | GE65DV564S |
| DrugBank ID | DB14634 |
Formulation & handling
- Fluprednidene acetate is a small molecule corticosteroid intended primarily for topical formulations such as creams and ointments.
- Due to its low water solubility and moderate lipophilicity (LogP 1.85), appropriate excipients should be selected to optimize skin penetration and formulation stability.
- It is not suitable for oral or injectable use and requires protection from moisture and extreme temperatures to maintain stability.
Regulatory status
Fluprednidene acetate is a type of Corticosteroids
Corticosteroids are a vital subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in the field of medicine. These synthetic drugs mimic the effects of hormones naturally produced by the adrenal glands. Corticosteroids exhibit potent anti-inflammatory and immunosuppressive properties, making them widely used in the treatment of various medical conditions.
The main therapeutic applications of corticosteroids include the management of inflammatory disorders such as asthma, rheumatoid arthritis, and dermatological conditions like eczema and psoriasis. They are also employed in the treatment of allergic reactions, organ transplantations, and certain types of cancer.
Corticosteroids function by inhibiting the production of inflammatory mediators and suppressing immune responses. They act on specific receptors present in cells throughout the body, modulating gene expression and influencing various metabolic processes. These APIs are available in various formulations, including oral tablets, injectables, inhalers, nasal sprays, and topical creams.
It is crucial to note that corticosteroids must be prescribed and used under medical supervision due to their potential side effects, which can include adrenal suppression, osteoporosis, increased susceptibility to infections, and glucose intolerance. The dosage and duration of treatment vary depending on the condition being treated, and physicians carefully monitor patients to minimize any adverse effects.
In summary, corticosteroids are a vital class of pharmaceutical APIs with powerful anti-inflammatory and immunosuppressive properties. They are extensively used in the treatment of diverse medical conditions, providing relief to patients worldwide. However, their usage requires careful consideration and medical supervision to ensure optimal outcomes and minimize potential risks.
Fluprednidene acetate (Corticosteroids), classified under Respiratory Tract Agents
Respiratory Tract Agents are a vital category of pharmaceutical APIs (Active Pharmaceutical Ingredients) designed to treat respiratory conditions and diseases. These agents are specifically formulated to target the respiratory system, which includes the lungs, airways, and nasal passages. They play a crucial role in managing various respiratory disorders, such as asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis.
Respiratory Tract Agents encompass a wide range of medications, including bronchodilators, corticosteroids, antihistamines, and mucolytics. Bronchodilators are commonly used to relieve airway constriction and facilitate smooth breathing by relaxing the muscles in the airways. Corticosteroids help reduce inflammation in the respiratory system, alleviating symptoms and preventing exacerbations. Antihistamines work by blocking histamine receptors, thus mitigating allergic reactions that often impact the respiratory tract. Mucolytics aid in loosening and thinning mucus, making it easier to expel from the airways.
These APIs are developed through rigorous research and development processes, ensuring their efficacy, safety, and compliance with regulatory standards. Pharmaceutical manufacturers rely on advanced technologies and stringent quality control measures to produce high-quality Respiratory Tract Agents. These APIs are subsequently incorporated into various dosage forms, including inhalers, nasal sprays, nebulizers, and oral medications.
Respiratory Tract Agents are essential in the management of respiratory conditions, providing relief from symptoms, improving lung function, and enhancing the overall quality of life for patients. They are prescribed by healthcare professionals and often used in combination therapies to achieve optimal results. As respiratory disorders continue to affect a significant portion of the global population, the development and availability of effective Respiratory Tract Agents play a vital role in addressing these health challenges and improving patient outcomes.
Fluprednidene acetate API manufacturers & distributors
Compare qualified Fluprednidene acetate API suppliers worldwide. We currently have 2 companies offering Fluprednidene acetate API, with manufacturing taking place in 2 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Cambrex | Producer | Italy | United States | CoA, GMP | 104 products |
| Farmabios | Producer | Italy | Italy | CoA, GMP | 58 products |
When sending a request, specify which Fluprednidene acetate API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Fluprednidene acetate API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
