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Methylprednisolone Aceponate API Manufacturers & Suppliers

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Commercial-scale Suppliers

Producer
Produced in  India
|

Employees: 200+

|
Audit Report: Currently Eurofins has no report for this supplier. Contact them to let them know you're interested!
Certifications: GMP
|
MSDS
|
BSE/TSE
|
CoA

All certificates

GMP
MSDS
BSE/TSE
CoA
Producer
Produced in  Spain
|

Employees: 3,500+

|
Audit Report: Click here for more information on Eurofins audit reports
Certifications: GMP
|
EDMF/ASMF
|
MSDS
|
CoA

All certificates

GMP
EDMF/ASMF
MSDS
CoA
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Methylprednisolone aceponate | CAS No: 86401-95-8 | GMP-certified suppliers

A medication that provides potent anti-inflammatory and immunosuppressive effects for topical treatment of corticosteroid-responsive inflammatory and pruritic skin conditions.

Therapeutic categories

Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroidsCorticosteroids, Dermatological PreparationsCorticosteroids, Potent (Group III)Dermatologicals
Generic name
Methylprednisolone aceponate
Molecule type
small molecule
CAS number
86401-95-8
DrugBank ID
DB14643
Approval status
Approved drug, Vet_approved drug
ATC code
D07AC14

Product Snapshot

  • Methylprednisolone aceponate is available in topical formulation types including creams, ointments, lotions, solutions, and emulsions designed for cutaneous application
  • It is primarily used for anti-inflammatory and immunosuppressive indications in dermatological conditions
  • The compound holds both human and veterinary approvals, with regulatory status including general market authorization

Clinical Overview

Methylprednisolone aceponate is a synthetic corticosteroid classified under adrenal cortex hormones and potent corticosteroids primarily used in dermatological preparations. Its chemical structure is based on a hydroxylated prostane moiety, placing it within the broader family of gluco/mineralocorticoids, progestogens, and their derivatives.

While specific clinical indications for methylprednisolone aceponate are not detailed here, corticosteroids in this class are generally employed for their anti-inflammatory and immunosuppressive properties in topical treatments of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It is approved for use in both human and veterinary medicine, reflecting its applicability across different species.

The mechanism of action of methylprednisolone aceponate involves its interaction with glucocorticoid receptors, leading to the modulation of gene expression that suppresses inflammatory cytokines and immune cell activation, although exact pharmacodynamics have not been specified. This corticosteroid acts at the cellular level to reduce inflammation and immune responses in affected tissues.

Pharmacokinetic data, including absorption, distribution, metabolism, and excretion (ADME) parameters, are not explicitly defined for methylprednisolone aceponate. However, topical corticosteroids typically exhibit limited systemic absorption with rapid local metabolism, minimizing systemic exposure and associated adverse effects when used appropriately.

Safety and toxicity considerations include the known class effects of potent topical corticosteroids such as local skin atrophy, telangiectasia, and potential hypothalamic-pituitary-adrenal (HPA) axis suppression on prolonged or widespread use. Appropriate dosing regimens and duration of therapy should be strictly observed to mitigate these risks.

From a sourcing and quality perspective, methylprednisolone aceponate APIs must conform to rigorous purity and stability standards due to its potent pharmacological activity and narrow therapeutic margins. Suppliers should provide comprehensive certificates of analysis demonstrating compliance with current pharmacopeial specifications and regulatory guidelines to ensure consistent quality for formulation and regulatory approval processes.

Identification & chemistry

Generic name Methylprednisolone aceponate
Molecule type Small molecule
CAS 86401-95-8
UNII ET54W9J4U2
DrugBank ID DB14643

Formulation & handling

  • Methylprednisolone aceponate is a small molecule corticosteroid primarily formulated for topical and cutaneous application, with some oral solution forms also available.
  • The compound exhibits low water solubility and moderate lipophilicity (LogP 3.14), influencing formulation strategies for dermal penetration and bioavailability.
  • Due to its steroid structure, it requires protection from light and oxidation during handling to maintain stability and efficacy.

Regulatory status

Methylprednisolone Aceponate is a type of Corticosteroids


Corticosteroids are a vital subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in the field of medicine. These synthetic drugs mimic the effects of hormones naturally produced by the adrenal glands. Corticosteroids exhibit potent anti-inflammatory and immunosuppressive properties, making them widely used in the treatment of various medical conditions.

The main therapeutic applications of corticosteroids include the management of inflammatory disorders such as asthma, rheumatoid arthritis, and dermatological conditions like eczema and psoriasis. They are also employed in the treatment of allergic reactions, organ transplantations, and certain types of cancer.

Corticosteroids function by inhibiting the production of inflammatory mediators and suppressing immune responses. They act on specific receptors present in cells throughout the body, modulating gene expression and influencing various metabolic processes. These APIs are available in various formulations, including oral tablets, injectables, inhalers, nasal sprays, and topical creams.

It is crucial to note that corticosteroids must be prescribed and used under medical supervision due to their potential side effects, which can include adrenal suppression, osteoporosis, increased susceptibility to infections, and glucose intolerance. The dosage and duration of treatment vary depending on the condition being treated, and physicians carefully monitor patients to minimize any adverse effects.

In summary, corticosteroids are a vital class of pharmaceutical APIs with powerful anti-inflammatory and immunosuppressive properties. They are extensively used in the treatment of diverse medical conditions, providing relief to patients worldwide. However, their usage requires careful consideration and medical supervision to ensure optimal outcomes and minimize potential risks.


Methylprednisolone Aceponate (Corticosteroids), classified under Respiratory Tract Agents


Respiratory Tract Agents are a vital category of pharmaceutical APIs (Active Pharmaceutical Ingredients) designed to treat respiratory conditions and diseases. These agents are specifically formulated to target the respiratory system, which includes the lungs, airways, and nasal passages. They play a crucial role in managing various respiratory disorders, such as asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis.

Respiratory Tract Agents encompass a wide range of medications, including bronchodilators, corticosteroids, antihistamines, and mucolytics. Bronchodilators are commonly used to relieve airway constriction and facilitate smooth breathing by relaxing the muscles in the airways. Corticosteroids help reduce inflammation in the respiratory system, alleviating symptoms and preventing exacerbations. Antihistamines work by blocking histamine receptors, thus mitigating allergic reactions that often impact the respiratory tract. Mucolytics aid in loosening and thinning mucus, making it easier to expel from the airways.

These APIs are developed through rigorous research and development processes, ensuring their efficacy, safety, and compliance with regulatory standards. Pharmaceutical manufacturers rely on advanced technologies and stringent quality control measures to produce high-quality Respiratory Tract Agents. These APIs are subsequently incorporated into various dosage forms, including inhalers, nasal sprays, nebulizers, and oral medications.

Respiratory Tract Agents are essential in the management of respiratory conditions, providing relief from symptoms, improving lung function, and enhancing the overall quality of life for patients. They are prescribed by healthcare professionals and often used in combination therapies to achieve optimal results. As respiratory disorders continue to affect a significant portion of the global population, the development and availability of effective Respiratory Tract Agents play a vital role in addressing these health challenges and improving patient outcomes.



Methylprednisolone Aceponate API manufacturers & distributors

Compare qualified Methylprednisolone Aceponate API suppliers worldwide. We currently have 2 companies offering Methylprednisolone Aceponate API, with manufacturing taking place in 2 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.

SupplierTypeCountryProduct originCertificationsPortfolio
Producer
United States Spain CoA, EDMF/ASMF, GMP, MSDS106 products
Producer
India India BSE/TSE, CoA, GMP, MSDS166 products

When sending a request, specify which Methylprednisolone Aceponate API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).

Use the list above to find high-quality Methylprednisolone Aceponate API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.