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Looking for Glucarpidase API 9074-87-7?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Glucarpidase. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Glucarpidase
- Synonyms:
- Folate hydrolase G2 , Glutamate carboxypeptidase
- Cas Number:
- 9074-87-7
- DrugBank number:
- DB08898
- Unique Ingredient Identifier:
- 2GFP9BJD79
About Glucarpidase
It's time for some technical information for the ones who understand chemistry: Glucarpidase is the recombinant form of the Pseudomonas sp. (strain RS-16) enzyme carboxypeptidase G2 that is produced in Escherichia coli. In patients, glucarpidase inactivates methotrexate, and other antifolates, by hydrolyzing glutamate on the carboxyl terminal of these compounds. Therefore since methotrexate is eliminated enzymatically and not by the kidneys, glucarpidase is indicated in patients on methotrexate treatment who have kidney dysfunction, and are experiencing an abnormally high plasma concentration of methotrexate (<1 micromole per liter).
Glucarpidase is marketed under the brand name Voraxaze®.
You can ask the supplier about all relevant certificates for the product such as CoA, Safety Data Sheet and DMF.
Glucarpidase is a type of Detoxifiers in oncolytics
Detoxifiers in oncolytics are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in cancer treatment. These detoxifiers are specifically designed to remove or neutralize harmful substances in the body, including carcinogens and toxins, thereby aiding in the detoxification process during oncolytic therapy.
The primary objective of detoxifiers in oncolytics is to enhance the effectiveness of cancer treatments while minimizing the side effects associated with chemotherapy and other therapies. By eliminating or reducing the presence of toxins in the body, these APIs promote the body's natural ability to fight cancer and enhance the overall treatment outcome.
Detoxifiers in oncolytics function through various mechanisms, such as enzymatic reactions, oxidation, reduction, conjugation, or binding with specific molecular targets. These mechanisms allow the detoxifiers to facilitate the breakdown or elimination of toxic substances and their metabolites from the body, ultimately reducing the toxic burden on healthy tissues and organs.
Pharmaceutical companies invest significant efforts in developing and manufacturing detoxifiers in oncolytics, ensuring their safety, efficacy, and compliance with regulatory standards. The ongoing research in this field aims to identify novel detoxifiers with improved specificity, selectivity, and reduced adverse effects. Furthermore, the combination of detoxifiers with other oncolytic agents and targeted therapies holds promising prospects in the field of cancer treatment.
In conclusion, detoxifiers in oncolytics are a vital component of cancer treatment regimens, playing a crucial role in enhancing therapeutic outcomes while minimizing the toxic effects of cancer therapies. The continuous advancements in this subcategory of pharmaceutical APIs hold great potential for improving the overall effectiveness and safety of cancer treatments.
Glucarpidase (Detoxifiers in oncolytics), classified under Anticancer drugs
Anticancer drugs belong to the pharmaceutical API (Active Pharmaceutical Ingredient) category designed specifically to combat cancer cells. These powerful medications play a crucial role in cancer treatment and are developed to target and destroy cancerous cells, preventing their growth and spread.
Anticancer drugs are classified based on their mode of action and can include various types such as chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, and hormonal therapy drugs. Chemotherapy drugs work by interfering with the cell division process, thereby inhibiting the growth of cancer cells. Targeted therapy drugs, on the other hand, are designed to attack specific molecules or genes involved in cancer growth, minimizing damage to healthy cells. Immunotherapy drugs stimulate the body's immune system to recognize and destroy cancer cells. Hormonal therapy drugs are used in cancers that are hormone-dependent, such as breast or prostate cancer, to block the hormones that fuel cancer cell growth.
These APIs are typically synthesized through complex chemical processes in state-of-the-art manufacturing facilities. Stringent quality control measures ensure the purity, potency, and safety of these drugs. Anticancer APIs undergo rigorous testing and adhere to stringent regulatory guidelines before being approved for clinical use.
Due to their critical role in cancer treatment, anticancer drugs are in high demand worldwide. Researchers and pharmaceutical companies continually strive to develop new and more effective APIs in this category to enhance treatment outcomes and minimize side effects. The ongoing advancements in the field of anticancer drug development offer hope for improved cancer therapies and better patient outcomes.
Glucarpidase manufacturers | traders | suppliers
We have 1 companies offering Glucarpidase produced in 1 different countries.
Get in contact with the supplier of your choice:
- Sigma-Aldrich from United States, product country of origin Unknown
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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