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Ademetionine | CAS No: 29908-03-0 | GMP-certified suppliers
A medication that supports treatment of depression, liver disorders, fibromyalgia, and osteoarthritis while promoting bone, joint, and mood health.
Therapeutic categories
Primary indications
- S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis
- It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being
Product Snapshot
- Ademetionine is available as oral tablets with delayed release and injectable solutions for intravenous and intramuscular administration
- It is primarily used for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis
- The pharmaceutical forms are approved in Europe, with investigational and nutraceutical status in other markets including the United States
Clinical Overview
Clinically, ademetionine has established applications in several therapeutic areas. In Europe, it is approved for use in treating depression, chronic liver disorders, fibromyalgia, and osteoarthritis. In the United States, it is primarily marketed as a dietary supplement supporting bone and joint health, as well as mood and emotional well-being, reflecting its diverse pharmacological roles.
The pharmacological activity of ademetionine centers on its role as an intermediate metabolite of methionine. It facilitates methylation reactions critical for cellular growth, repair processes, and maintenance of the phospholipid bilayer in cell membranes. SAMe also modulates the function of various hormones and neurotransmitters that influence mood regulation, with the highest concentrations found in hepatic and cerebral tissues.
Mechanistically, ademetionine is synthesized intracellularly from L-methionine and ATP via the enzyme S-adenosylmethionine synthetase. It donates a methyl group through transmethylation to substrates including DNA, RNA, epinephrine, melatonin, and creatine, participating in numerous biosynthetic and regulatory pathways.
Regarding ADME, detailed human pharmacokinetic data are limited, but as an endogenous molecule, ademetionine is processed via cellular metabolic pathways and exhibits tissue-specific distribution primarily in the liver and brain. Safety profiles indicate a generally favorable tolerability, with rare adverse effects predominantly related to gastrointestinal discomfort or hypersensitivity. There is some evidence of weak inhibition of cytochrome P450 enzyme CYP2E1, which may be relevant in drug interaction contexts.
For API sourcing and quality control, it is critical to ensure high purity standards given the compound's chemical lability and sensitivity to oxidation. Suppliers should provide full characterization data, including certification of analysis confirming chemical identity, assay, and absence of contaminants. Stability under storage and handling conditions must be validated due to ademetionine’s susceptibility to degradation. Compliance with pharmacopeial or relevant regulatory standards is essential for pharmaceutical-grade material used in formulation and clinical applications.
Identification & chemistry
| Generic name | Ademetionine |
|---|---|
| Molecule type | Small molecule |
| CAS | 29908-03-0 |
| UNII | 7LP2MPO46S |
| DrugBank ID | DB00118 |
Pharmacology
| Summary | S-Adenosylmethionine (SAMe) is an endogenous metabolite that donates methyl groups in transmethylation reactions essential for biosynthesis of nucleic acids, proteins, and neurotransmitters. It modulates enzyme targets involved in methylation processes that support cellular growth, membrane integrity, and regulation of mood-related hormones and neurotransmitters. Therapeutically, SAMe is utilized for its role in managing depression, liver disorders, and musculoskeletal conditions by influencing biochemical pathways central to cellular repair and neurochemical balance. |
|---|---|
| Mechanism of action | S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules. |
| Pharmacodynamics | S-adenosylmethionine is an intermediate metabolite of methionine. Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several hormones and neurotransmitters that affect mood. Highest concentration are found in the brain and the liver. |
Targets
| Target | Organism | Actions |
|---|---|---|
| Catechol O-methyltransferase | Humans | cofactor |
| Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | Humans | |
| Arsenite methyltransferase | Humans |
ADME / PK
| Absorption | S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Bioavailability is low following oral intake. |
|---|---|
| Metabolism | Significant first-pass metabolism in the liver. Approximately 50% of S-Adenosylmethionine (SAMe) is metabolized in the liver. SAMe is metabolized to S-adenosylhomocysteine, which is then metabolized to homocysteine. Homocysteine can either be metabolized to cystathionine and then cysteine or to methionine. The cofactor in the metabolism of homocysteine to cysteine is vitamin B6. Cofactors for the metabolism of homocysteine to methionine are folic acid, vitamin B12 and betaine. |
Formulation & handling
- Ademetionine is available for both oral administration in delayed-release tablets and parenteral administration via intramuscular or intravenous injection.
- As a small molecule with high water solubility and low LogP, it is suitable for formulation in aqueous injectable solutions.
- Delayed-release oral formulations suggest sensitivity to gastric conditions, requiring protection from early stomach degradation.
Regulatory status
Supply Chain
| Supply chain summary | Ademetionine is supplied by multiple originator companies with branded products available in the US, EU, and other global markets. The presence of established packagers indicates a well-developed supply chain. Patent expirations have facilitated the entry of generic competitors, expanding sourcing options within the active pharmaceutical ingredient marketplace. |
|---|
Safety
| Toxicity | Irritating to mucus membranes and upper respiratory tract. Can cause CNS depression. |
|---|
- Irritant to mucous membranes and upper respiratory tract
- Appropriate respiratory protection recommended during handling
- Potential CNS depressant effects
S-Adenosylmethionine is a type of Dietary supplements
Dietary supplements are a subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs) that play a crucial role in supporting overall health and well-being. These supplements are formulated to provide essential nutrients, vitamins, minerals, and other bioactive compounds that may be lacking in an individual's regular diet.
Dietary supplements are designed to bridge the nutritional gaps and promote optimal health by enhancing various bodily functions. They come in various forms, including tablets, capsules, powders, and liquids, and are commonly available over-the-counter.
These supplements often contain key ingredients such as vitamins (e.g., Vitamin C, Vitamin D), minerals (e.g., calcium, iron), antioxidants, herbal extracts, probiotics, and omega-3 fatty acids. Each ingredient is carefully selected for its specific health benefits and therapeutic effects.
When taken as directed, dietary supplements can support immune function, boost energy levels, promote healthy digestion, support cardiovascular health, and provide numerous other benefits. However, it's important to note that these supplements are not intended to replace a balanced diet but rather complement it.
Before incorporating dietary supplements into one's routine, it is recommended to consult with a healthcare professional to ensure they are appropriate for individual needs and to avoid potential interactions with any existing medications or health conditions.
In conclusion, dietary supplements are a vital category of pharmaceutical APIs that offer a convenient and effective way to supplement nutritional intake and promote overall well-being. When used responsibly, these supplements can play a valuable role in maintaining optimal health.
S-Adenosylmethionine (Dietary supplements), classified under Therapeutic Nutrients/Minerals/Electrolyte
Therapeutic Nutrients/Minerals/Electrolytes: A Comprehensive Technical DescriptionTherapeutic nutrients, minerals, and electrolytes are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) used to support and enhance overall health and well-being. These compounds play a crucial role in maintaining the body's physiological balance, aiding in various metabolic processes, and addressing specific deficiencies.
Therapeutic nutrients encompass a broad range of substances, including vitamins, minerals, and electrolytes. Vitamins are organic compounds required in small quantities for proper bodily functions and are essential for growth, development, and disease prevention. Minerals, on the other hand, are inorganic substances that support numerous physiological processes, such as bone formation, nerve function, and energy production.
Electrolytes are minerals that carry an electric charge when dissolved in bodily fluids, including sodium, potassium, calcium, magnesium, and chloride. They play a crucial role in maintaining proper hydration, nerve impulses, muscle contractions, and pH balance.
Pharmaceutical APIs in the Therapeutic Nutrients/Minerals/Electrolyte category are designed to address specific deficiencies or imbalances in the body. These APIs are often used in the formulation of dietary supplements, nutritional products, and therapeutic treatments. They are manufactured under stringent quality control guidelines to ensure purity, potency, and bioavailability.
Therapeutic nutrients/minerals/electrolytes APIs are available in various forms, including tablets, capsules, powders, and liquid formulations. They are formulated to meet specific dosage requirements and can be combined with other ingredients for targeted health benefits.
Overall, therapeutic nutrients, minerals, and electrolytes APIs are essential components in maintaining optimal health. Their use helps address deficiencies, support bodily functions, and promote overall well-being. Pharmaceutical companies and healthcare professionals rely on these high-quality APIs to develop effective and safe products that contribute to a healthier population.
S-Adenosylmethionine API manufacturers & distributors
Compare qualified S-Adenosylmethionine API suppliers worldwide. We currently have 1 companies offering S-Adenosylmethionine API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Zhejiang Hisun Pharma | Producer | China | China | CoA, WC | 69 products |
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